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首页> 外文期刊>Journal of Neurophysiology >Phase response curves of subthalamic neurons measured with synaptic input and current injection
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Phase response curves of subthalamic neurons measured with synaptic input and current injection

机译：突触输入和电流注入测量的丘脑下神经元的相位响应曲线

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Infinitesimal phase response curves (iPRCs) provide a simple description of the response of repetitively firing neurons and may be used to predict responses to any pattern of synaptic input. Their simplicity makes them useful for understanding the dynamics of neurons when certain conditions are met. For example, the sizes of evoked phase shifts should scale linearly with stimulus strength, and the form of the iPRC should remain relatively constant as firing rate varies. We measured the PRCs of rat subthalamic neurons in brain slices using corticosubthalamic excitatory postsynaptic potentials (EPSPs; mediated by both AMPA- and NMDA-type receptors) and injected current pulses and used them to calculate the iPRC. These were relatively insensitive to both the size of the stimulus and the cell's firing rate, suggesting that the iPRC can predict the response of subthalamic nucleus cells to extrinsic inputs. However, the iPRC calculated using EPSPs differed from that obtained using current pulses. EPSPs (normalized for charge) were much more effective at altering the phase of subthalamic neurons than current pulses. The difference was not attributable to the extended time course of NMDA receptor-mediated currents, being unaffected by blockade of NMDA receptors. The iPRC provides a good description of subthalamic neurons' response to input, but iPRCs are best estimated using synaptic inputs rather than somatic current injection.
机译：无限小相位响应曲线（iPRC）提供了重复触发神经元响应的简单描述，可用于预测对任何突触输入模式的响应。当满足某些条件时，它们的简单性使它们对于理解神经元的动力学很有用。例如，诱发相移的大小应与刺激强度成线性比例，并且随着发射速率的变化，iPRC的形式应保持相对恒定。我们使用皮下丘脑兴奋性突触后电位（EPSPs;由AMPA型和NMDA型受体介导）测量了脑切片中大鼠丘脑下神经元的PRCs，并注入了电流脉冲，并用它们来计算iPRC。这些对刺激的大小和细胞的发射速率都相对不敏感，这表明iPRC可以预测丘脑下核细胞对外部输入的反应。但是，使用EPSP计算的iPRC与使用电流脉冲获得的iPRC不同。 EPSP（电荷归一化）在改变丘脑下神经元的相位方面比电流脉冲更有效。差异不归因于不受NMDA受体影响的NMDA受体介导的电流时间延长。 iPRC很好地描述了丘脑下神经元对输入的响应，但是iPRC最好使用突触输入而不是体电流注入来估计。

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