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首页> 外文期刊>Journal of Neurophysiology >Primate red nucleus discharge encodes the dynamics of limb muscle activity.
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Primate red nucleus discharge encodes the dynamics of limb muscle activity.

机译：灵长类红色核放电编码肢体肌肉活动的动态。

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摘要

We studied the dynamical relationship between magnocellular red nucleus (RNm) discharge and electromyographic (EMG) activity of 10-15 limb muscles in two monkeys during voluntary limb movement. Recordings were made from 158 neurons during two different kinds of limb movement tasks. One was a tracking task in which the subjects were required to acquire targets displayed on an oscilloscope by rotating one of six different single degree of freedom manipulanda. During this task, we recorded the angular position of the manipulandum. The monkeys also were trained in several free-form food-retrieval tasks that were much less constrained mechanically. There was generally significantly greater neuronal discharge during the free-form tasks than during the tracking task. During both types of tasks, cross-correlation and impulse response functions calculated between RNm and EMG were predominantly pulse-shaped, indicating that the dynamics of the RNm discharge were very similar to those of the muscle activity. There was no evidence during either task for a substantial dynamical transformation (e.g., integration) between the two signals as had been previously suggested. In only 15% of the cases, did these correlations have step or pulse-step dynamics. There was a relatively broad, unimodal distribution of lag times between RNm and EMG, based on the time of occurrence of the peak correlation. During tracking, the mode of this distribution was approximately 50 ms, with 80% of the lags falling between -100 and 200 ms. During the free-form task, the mode was between 0 and 20 ms, with 65% of the lags between -100 and 200 ms. A positive lag indicates that RNm discharge preceded EMG. The shape and timing of both the cross-correlation and the impulse response functions were consistent with a model in which many RNm neurons contribute mutually correlated signals which are simply summed within the spinal cord to produce a muscle activation signal.
机译：我们研究了两只猴子在自愿肢体运动过程中大细胞红核（RNm）放电与10-15肢体肌肉的肌电图（EMG）活性之间的动力学关系。在两种不同类型的肢体运动任务中，从158个神经元进行了记录。一种是跟踪任务，其中要求受试者通过旋转六个不同的单自由度操作之一来获取示波器上显示的目标。在此任务中，我们记录了Manipulandum的角位置。猴子还接受了几种自由形式的食物检索任务的训练，这些任务在机械上的约束要少得多。与跟踪任务相比，自由形式任务期间的神经元放电通常明显更大。在这两种类型的任务中，RNm和EMG之间计算的互相关和冲激响应函数主要是脉冲形的，这表明RNm放电的动力学与肌肉活动的动力学非常相似。如前所述，在任何一项任务期间都没有证据表明两个信号之间有实质性的动态转换（例如，积分）。在只有15％的情况下，这些相关性是否具有阶跃或脉冲阶跃动态。根据出现峰值相关的时间，RNm和EMG之间存在相对较宽的单峰滞后时间分布。在跟踪过程中，此分布的模式约为50毫秒，其中80％的滞后时间介于-100到200毫秒之间。在自由形式任务期间，该模式在0到20毫秒之间，滞后的65％在-100到200毫秒之间。正滞后表明RNm放电先于EMG。互相关和冲激响应函数的形状和时间与一个模型一致，在该模型中，许多RNm神经元贡献了相互关联的信号，这些信号被简单地累加在脊髓内以产生肌肉激活信号。

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