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首页> 外文期刊>Journal of Neurophysiology >Dynamic properties of corticothalamic neurons and local cortical interneurons generating fast rhythmic (30-40 Hz) spike bursts.
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Dynamic properties of corticothalamic neurons and local cortical interneurons generating fast rhythmic (30-40 Hz) spike bursts.

机译：皮层丘脑神经元和局部皮层神经元的动态特性，产生快速的有节奏的（30-40 Hz）尖峰爆发。

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Fast spontaneous oscillations (mainly 30-40 Hz) characterize cortical and thalamic neuronal networks during behavioral states of increased vigilance and depend on cell depolarization under the influence of ascending activating systems. We investigated, by means of intracellular recording and staining in vivo, the properties of fast-oscillating cortical neurons from cat's motor and association areas, some projecting to the thalamus, others with locally arborizing axons. At a given level of depolarization, 28% of our neuronal sample discharged high-frequency spike bursts (300-600 Hz) that recurred rhythmically between 20 and 50 Hz. Such fast rhythmic bursting neurons have been found in both superficial and deep cortical layers. Slight changes in membrane potential as well as synaptic activity in thalamocortical networks dramatically altered the discharge patterns, from single spikes to rhythmic spike-bursts, and eventually to fast tonic firing without frequency adaptation. Thus our data challenge the conventional idea that sharply defined, invariant features and distinct locations in certain cortical layers characterize some neocortical cell-classes. We demonstrate that the distinctions between intrinsic electrophysiological properties of neocortical neurons are much more labile than conventionally thought. The present results, which indicate that corticothalamic neurons discharge fast rhythmic spike bursts mainly at 30-40 Hz, suggest that this activity results in integrated fast oscillations within corticothalamic networks.
机译：快速的自发振荡（主要是30-40 Hz）是在警觉性增强的行为状态下表征皮层和丘脑神经网络的特性，并且取决于在激活系统提升下细胞的去极化作用。我们通过体内细胞内记录和染色的方法，研究了来自猫运动区和关联区的快速振荡的皮质神经元的特性，其中一些投射到丘脑，其他投射在局部乔树轴突上。在给定的去极化水平下，我们神经元样本中的28％释放了高频尖峰脉冲（300-600 Hz），该脉冲在20至50 Hz之间有节奏地重复出现。在表层和深层皮质中都发现了这种快速的有节奏的爆发性神经元。丘脑皮层网络中膜电位的轻微变化以及突触活性极大地改变了放电模式，从单个尖峰到有节奏的尖峰爆发，最终变为快速的无频率适应性强音发射。因此，我们的数据挑战了传统观念，即某些皮质层中清晰定义的不变特征和不同位置是某些新皮质细胞类别的特征。我们证明新皮层神经元的固有电生理特性之间的区别比传统上认为的要不稳定得多。目前的结果表明，皮层丘脑神经元主要在30-40 Hz处释放快速的节律性尖峰脉冲，表明该活动导致了皮层丘脑网络内的整体快速振荡。

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