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首页> 外文期刊>Journal of Neurophysiology >Selective induction of LTP and LTD by postsynaptic (Ca2+)i elevation.
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Selective induction of LTP and LTD by postsynaptic (Ca2+)i elevation.

机译：突触后（Ca2 +）i升高对LTP和LTD的选择性诱导。

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摘要

Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca2+]i). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca2+]i elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca2+]i with relatively high magnitude, which mimics the [Ca2+]i rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca2+]i reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information.
机译：长期增强（LTP）和长期抑制（LTD）是谷氨酸能传入CA1海马锥体细胞时突触可塑性的两种主要形式，都是由突触后细胞内钙浓度（[Ca2 +] i）升高触发的。为了了解一个信号分子如何引起两种相反形式的突触调节，新的笼状钙化合物硝基苯基-乙二醇-双（β-氨基乙基醚）-N，N产生了不同的突触后[Ca2 +] i升高模式。 CA1锥体细胞中的，N'，N'-四乙酸。我们发现[Ca2 +] i升高的特定模式选择性激活LTP或LTD。特别是，只有LTP由[Ca2 +] i的短暂增加触发，幅度相对较高，这类似于通常用于诱导LTP的电刺激过程中[Ca2 +] i的增加。相反，[Ca2 +] i的持续适度上升可靠地诱导了LTD。结果的重要含义是细胞内化学信号的幅度和持续时间都可以携带重要的生物学信息。

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