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首页> 外文期刊>Journal of Neurophysiology >Deficits in smooth-pursuit eye movements after muscimol inactivation within the primate's frontal eye field.
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Deficits in smooth-pursuit eye movements after muscimol inactivation within the primate's frontal eye field.

机译：灵长类动物的额眼视野内的麝香酚失活后，追求平滑的眼球运动不足。

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摘要

To evaluate smooth-pursuit (SP) function in the primate frontal eye field (FEF), microinjections of muscimol, a gamma-aminobutyric acid (GABA) agonist, were used to reversibly deactivate physiologically characterized sites in FEF. SP was severely impaired by deactivation at sites in the FEF's smooth eye movement region (FEFsem) located in the fundus and posterior bank of the macaque monkey's arcuate sulcus. These SP deficits were apparent immediately after the muscimol injection and persisted for several hours but recovered by the next day. SP was most drastically and consistently impaired for directions similar to the injected site's elicited smooth eye movement direction or to the optimal SP direction for its neuronal responses. Targets moving in these directions, usually ipsilateral to the injected hemisphere, were tracked primarily with saccades after the muscimol injection, the peak SP velocity being only 10-30% of preinjection velocity. SP in other directions, including contralateral, was less strongly affected. Initial SP acceleration in response to target motion onset was also significantly diminished, generally by approximately the same proportion as peak SP velocity. In contrast, saccades were largely unaffected by muscimol injections in FEFsem; nor was there an immediate effect on SP when control sites in the saccadic region of FEF (FEFsac) were deactivated, although a SP deficit often appeared 30-60 min after FEFsac injections, possibly reflecting diffusion of muscimol into neighboring FEFsem. These reversible SP deficits produced by muscimol inactivation within FEFsem are similar to permanent deficits caused by large aspiration lesions of FEF and indicate that inclusion of FEFsem is the critical factor determining whether FEF lesions impair SP. The severity of the reversible deficits found here indicates how extremely critical FEFsem is for normal highgain SP.
机译：为了评估在灵长类动物额叶视野（FEF）中的平滑追求（SP）功能，使用微注射麝香酚（一种γ-氨基丁酸（GABA）激动剂）可逆地失活FEF中的生理特征部位。由于位于猕猴弧形沟的眼底和后岸的FEF平滑眼球运动区域（FEFsem）的位置失活，严重损害了SP。麝香酚注射后这些SP缺陷立即显现，并持续数小时，但第二天恢复。对于与注射部位引起的平滑眼球运动方向相似的方向，或者对于其神经元反应的最佳SP方向，SP受到的影响最大且持续受到损害。沿muscimol注射后，主要通过扫视来跟踪沿这些方向移动的目标（通常与注射的半球同侧），峰值SP速度仅为注射前速度的10-30％。其他方向（包括对侧）的SP受到的影响较小。响应目标运动开始的初始SP加速度也显着降低，通常与SP峰值速度的比例大致相同。相比之下，扫视在很大程度上不受FEFsem中麝香酚注射的影响。当FEFsacadic区域（FEFsac）的控制位点失活时，对SP的影响也没有立即产生，尽管注射FEFsac后30-60分钟常常出现SP缺陷，这可能反映了麝香酚扩散到邻近的FEFsem中。由FEFsem中的muscimol失活产生的这些可逆的SP缺陷与由FEF的大量抽吸病变引起的永久性缺陷相似，并且表明包含FEFsem是确定FEF病变是否损害SP的关键因素。此处发现的可逆缺陷的严重程度表明，对于正常的高增益SP，FEFsem有多么关键。

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