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首页> 外文期刊>Journal of Neurophysiology >Physiological studies of spinohypothalamic tract neurons in the lumbar enlargement of monkeys.
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Physiological studies of spinohypothalamic tract neurons in the lumbar enlargement of monkeys.

机译：猴腰椎膨大中下丘脑下丘脑束神经元的生理研究。

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Recent anatomic results indicate that a large direct projection from the spinal cord to the hypothalamus exists in monkeys. The aim of this study was to determine whether the existence of this projection could be confirmed unambiguously using electrophysiological methods and, if so, to determine the response characteristics of primate spinohypothalamic tract (SHT) neurons. Fifteen neurons in the lumbar enlargement of macaque monkeys were antidromically activated using low-amplitude current pulses in the contralateral hypothalamus. The points at which antidromic activation thresholds were lowest were found in the supraoptic decussation (n = 13) or in the medial hypothalamus (n = 2). Recording points were located in the superficial dorsal horn (n = 1), deep dorsal horn (n = 10), and intermediate zone (n = 4). Each of the 12 examined neurons had cutaneous receptive fields on the ipsilateral hindlimb. All neurons responded exclusively or preferentially to noxious stimuli, suggesting that the transmission of nociceptive information is an important role of primate SHT axons. Twelve SHT neurons were also antidromically activated from the thalamus. In all cases, the antidromic latency from the thalamus was shorter than that from the hypothalamus, suggesting that the axons pass through the thalamus then enter the hypothalamus. These results confirm the existence of a SHT in primates and suggest that this projection may contribute to the production of autonomic, neuroendocrine, and emotional responses to noxious stimuli in primates, possibly including humans.
机译：最近的解剖结果表明，猴子存在着从脊髓到下丘脑的大量直接投射。这项研究的目的是确定是否可以使用电生理学方法明确确定该预测的存在，如果可以，则可以确定灵长类动物鼻下丘脑束（SHT）神经元的反应特征。使用对侧下丘脑中的低振幅电流脉冲，抗猕猴激活了猕猴的腰椎膨大中的15个神经元。反光激活阈值最低的点是在视上盲区（n = 13）或下丘脑内侧（n = 2）。记录点位于浅背角（n = 1），深背角（n = 10）和中间区域（n = 4）。检查的12个神经元中的每一个在同侧后肢上都有皮肤感受野。所有神经元都对有害刺激产生唯一或优先反应，这表明伤害性信息的传递是灵长类SHT轴突的重要作用。丘脑也从十二指肠激活了十二个SHT神经元。在所有情况下，丘脑的抗体质潜伏期均短于下丘脑的潜伏性潜伏期，这表明轴突穿过丘脑然后进入下丘脑。这些结果证实了灵长类动物中SHT的存在，并表明该推测可能有助于产生灵长类动物（可能包括人类）中有害刺激的自主神经，神经内分泌和情绪反应。

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