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首页> 外文期刊>Journal of Neurophysiology >Responses to rare visual target and distractor stimuli using event-related fMRI.
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Responses to rare visual target and distractor stimuli using event-related fMRI.

机译：使用事件相关功能磁共振成像对稀有视觉目标和干扰物刺激的反应。

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Previous studies have found that the P300 or P3 event-related potential (ERP) component is useful in the diagnosis and treatment of many disorders that influence CNS function. However, the anatomic locations of brain regions involved in this response are not precisely known. In the present event-related functional magnetic resonance imaging (fMRI) study, methods of stimulus presentation, data acquisition, and data analysis were optimized for the detection of brain activity in response to stimuli presented in the three-stimulus oddball task. This paradigm involves the interleaved, pseudorandom presentation of single block-letter target and distractor stimuli that previously were found to generate the P3b and P3a ERP subcomponents, respectively, and frequent standard stimuli. Target stimuli evoked fMRI signal increases in multiple brain regions including the thalamus, the bilateral cerebellum, and the occipital-temporal cortex as well as bilateral superior, medial, inferior frontal, inferior parietal, superior temporal, precentral, postcentral, cingulate, insular, left middle temporal, and right middle frontal gyri. Distractor stimuli evoked an fMRI signal change bilaterally in inferior anterior cingulate, medial frontal, inferior frontal, and right superior frontal gyri, with additional activity in bilateral inferior parietal lobules, lateral cerebellar hemispheres and vermis, and left fusiform, middle occipital, and superior temporal gyri. Significant variation in the amplitude and polarity of distractor-evoked activity was observed across stimulus repetitions. No overlap was observed between target- and distractor-evoked activity. These event-related fMRI results shed light on the anatomy of responses to target and distractor stimuli that have proven useful in many ERP studies of healthy and clinically impaired populations.
机译：先前的研究发现，P300或P3事件相关电位（ERP）组件可用于诊断和治疗许多影响CNS功能的疾病。但是，尚不清楚该反应涉及的大脑区域的解剖位置。在当前的事件相关功能磁共振成像（fMRI）研究中，针对三刺激奇异球任务中出现的刺激，优化了刺激呈现，数据采集和数据分析方法，以检测大脑活动。该范例涉及单个块字母目标和干扰物刺激的交错，伪随机表示，以前发现它们分别生成P3b和P3a ERP子组件以及频繁的标准刺激。目标刺激诱发的功能磁共振成像信号在包括丘脑，双侧小脑和枕颞皮以及双侧上，中，额下，顶下壁，颞上，中央，中央后，中央，扣带，小叶，左侧的多个大脑区域中增加颞中部和右额中回。牵张物刺激引起下前扣带回，内侧额叶，额额下回和右上额回的双侧功能性磁共振成像信号改变，在双侧下顶小叶，小脑外侧半球和mis骨，左梭状，枕骨上和颞上具有附加活动gyri。在整个刺激重复过程中，观察到干扰物诱发的活动的幅度和极性发生了显着变化。在目标和干扰物诱发的活动之间未观察到重叠。这些与事件相关的功能磁共振成像结果揭示了对靶标和干扰物刺激反应的解剖结构，这些解剖结构已被证明可用于健康和临床受损人群的许多ERP研究。

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