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首页> 外文期刊>Journal of Neurophysiology >Evidence for common expression mechanisms underlying heterosynaptic and associative long-term depression in the dentate gyrus.
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Evidence for common expression mechanisms underlying heterosynaptic and associative long-term depression in the dentate gyrus.

机译：齿状回异质突触和联想长期抑郁症背后的常见表达机制的证据。

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1. The extent to which heterosynaptic and prime-associative stimulation protocols generate different forms of long-term depression (LTD) was assessed in the lateral perforant path synapses terminating on dentate gyrus granule cells in pentobarbital-anesthetized rats. 2. Heterosynaptic LTD was induced in the lateral path by repeated tetanization of the medial path. Prime-associative LTD of the lateral path was induced by alternating high-frequency conditioning trains to the medial path and single shocks to the lateral path at 100-ms intervals, all occurring 10 min after priming stimulation of the lateral path (5 Hz, 80 pulses). 3. Induction of LTD by one administration of the prime-associative protocol was normally greater in magnitude than the LTD induced by the heterosynaptic protocol. Saturation of LTD by repeated delivery of the prime-associative protocol completely occluded the subsequent induction of LTD by the heterosynaptic protocol. Saturation of LTD by repeated delivery of the heterosynaptic protocol produced an 80% occlusion of the LTD generated by the prime-associative protocol. 4. These data support the hypothesis that activity-dependent (associative) and activity-independent (heterosynaptic) LTD involve overlapping expression mechanisms, despite having demonstrably different induction mechanisms.
机译：1.在终止于戊巴比妥麻醉的大鼠的齿状回颗粒细胞的横向穿孔路径突触中，评估了异突触和初级联想刺激方案产生不同形式的长期抑郁（LTD）的程度。 2.通过内侧路径的反复成钛作用，在外侧路径中诱发异突触LTD。横向路径的素数相关LTD是由交替的高频调节列车到内侧路径和对横向路径的单次电击以100-ms的间隔引起的，所有冲击都发生在对横向路径的启动刺激后10分钟（5 Hz，80脉冲）。 3.一次施用素-缔合方案引起的LTD的诱导通常比异突触方案引起的LTD在幅度上更大。通过重复递送最初的缔合方案使LTD饱和，从而完全阻止了后来通过异突触方案诱导LTD。通过重复传递异突触协议使LTD饱和，从而导致由初联协议生成的LTD发生80％的闭塞。 4.这些数据支持以下假设：尽管具有明显不同的诱导机制，但活性依赖性（缔合）和活性非依赖性（异突触）LTD涉及重叠的表达机制。

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