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首页> 外文期刊>Journal of Neurophysiology >Intracellular Ca2+ stores can account for the time course of LTP induction: a model of Ca2+ dynamics in dendritic spines.
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Intracellular Ca2+ stores can account for the time course of LTP induction: a model of Ca2+ dynamics in dendritic spines.

机译：细胞内Ca2 +储存可以解释LTP诱导的时间过程：树突棘中Ca2 +动态的模型。

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摘要

1. A model of Ca2+ dynamics in spines of CA1 hippocampal neurons is presented. In contrast to traditional models, which concentrate on the effects of Ca2+ influx, diffusion, buffering, and extrusion, we also consider the additional effect of intracellular Ca2+ stores. 2. It is shown that traditional models without Ca2+ stores cannot account for the time course of long-term potentiation (LTP) induction as found in recent experiments. Experimental data suggest that the intracellular Ca2+ concentration should be elevated for up to 2 s, whereas the Ca2+ concentration in standard models of Ca2+ dynamics decays much faster. 3. When intracellular Ca2+ stores are taken into account, a much slower decay is found. In particular, a model simulation with a stimulation paradigm consisting of two bursts of four impulses at 100 Hz each and variable interburst intervals can reproduce experimental results found for primed or theta-burst stimulation. 4. In our model, Ca2+ release from the store has a nonlinear, bell-shaped dependence on the intracellular Ca2+ concentration, similar to the one found for inositoltrisphosphate and ryanodine receptors. These receptors are known to control calcium release from intracellular stores. 5. Our model suggests an important role of intracellular calcium stores in the induction of LTP. The stores serve as a long-term calcium source that can sustain an intracellular Ca2+ concentration above the resting level for 1-2 s.
机译：1.提出了CA1海马神经元棘突中Ca2 +动力学的模型。与专注于Ca2 +流入，扩散，缓冲和挤压作用的传统模型相比，我们还考虑了细胞内Ca2 +储存的其他作用。 2.结果表明，没有Ca2 +存储的传统模型无法解决最近实验中发现的长期增强（LTP）诱导的时间过程。实验数据表明，细胞内Ca2 +浓度应提高2 s，而标准的Ca2 +动力学模型中的Ca2 +浓度衰减要快得多。 3.当考虑到细胞内Ca2 +存储时，发现衰变要慢得多。尤其是，具有刺激范式的模型仿真包含两个脉冲组，每个脉冲以100 Hz的频率分别有两个脉冲，每个脉冲有四个，每个脉冲组的间隔为100赫兹，脉冲间隔可变，可以重现激发或θ脉冲刺激的实验结果。 4.在我们的模型中，商店中的Ca2 +释放对细胞内Ca2 +浓度呈非线性，钟形依赖性，与肌醇三磷酸和ryanodine受体相似。已知这些受体可控制钙从细胞内存储中释放。 5.我们的模型表明细胞内钙存储在LTP诱导中的重要作用。这些储存库可作为长期的钙源，可将细胞内Ca2 +浓度维持在静止水平以上1-2秒。

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