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首页> 外文期刊>Journal of Neurophysiology >Neuronal activity in the supplementary eye field during acquisition of conditional oculomotor associations.
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Neuronal activity in the supplementary eye field during acquisition of conditional oculomotor associations.

机译：在条件性动眼神经联想的获取过程中，在补充眼场的神经元活动。

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1. The supplementary eye field (SEF) has been viewed as a premotor cortical field for the selection and control of saccadic eye movements. Drawing on studies of the neighboring premotor cortex, we hypothesized that if the SEF participates in the selection of action based on arbitrary stimulus-response associations, then task-related activity in the SEF should change during the learning of such associations. 2. Rhesus monkeys were operantly conditioned to make a saccadic eye movement to one of four targets (7 deg up, down, left, and right from center) in response to a foveal instruction stimulus (IS). One and only one of those four possible responses was arbitrarily designated "correct" for each IS. The monkeys responded to familiar ISs, four stimuli that remained unchanged throughout training and recording, as well as to novel ISs, which the monkeys had not previously seen. The monkeys initially chose responses to novel stimuli by trial and error, with near chance levels of performance, but quickly learned to select the correct saccade. 3. We studied 186 SEF cells as monkeys learned new visuomotor associations. Neuronal activity was quantified in four task periods: during the presentation of the IS, during an instructed delay period (i.e., after the removal of the IS but before a trigger or "go" stimulus), just before the saccade, and after the saccade during fixation of the target location. The discharge rate in each task period was considered a separate case for analysis, compared with that in a reference period preceding the IS, and eliminated from further analysis if not significantly different. 4. We observed two main categories of activity change during learning, which we termed learning selective and learning dependent. Learning-selective cases showed a significant evolution in activity as the monkeys learned which saccade was instructed by a novel IS, but had no significant modulation during trials with familiar ISs. Many of these cells were virtually inactive on trials with familiar ISs. However, they initially showed dramatic modulation when tested with a novel IS. As the monkey chose the correct saccade (or target) with increasing reliability, the modulation often decremented until the cell was again relatively unmodulated, as observed during familiar-IS trials. These cells usually remained relatively inactive until the monkeys were challenged to start learning another new stimulus-response association. Learning-selective activity was observed in all task periods, and 33 (18%) of the 186 adequately tested SEF cells showed learning-selective activity in one or more task periods.(ABSTRACT TRUNCATED AT 400 WORDS)
机译：1.辅助眼视野（SEF）被视为运动前皮质区域，用于选择和控制眼跳运动。借助对相邻运动前皮层的研究，我们假设，如果SEF参与基于任意刺激-响应关联的动作选择，则SEF中与任务相关的活动在学习此类关联时应发生变化。 2.响应中央凹指令刺激（IS），对恒河猴进行条件性调节，使其眼球向四个目标（从中心向上，向下，向左，向右和向右7度）中的一个进行眼动运动。对于每个IS，这四个可能的响应中只有一个是任意指定为“正确”。猴子对熟悉的IS，在训练和记录过程中保持不变的四个刺激以及新的IS（猴子以前从未见过）做出了反应。猴子最初通过反复试验来选择对新刺激的反应，表现接近机会水平，但很快就学会了选择正确的扫视镜。 3.当猴子学习到新的视觉运动联想时，我们研究了186个SEF细胞。在四个任务阶段对神经元活动进行了量化：在IS出现期间，在指示的延迟期内（即，在IS移除之后但在触发或“去”刺激之前），扫视之前和扫视之后在固定目标位置期间。与IS之前的参考期间相比，每个任务期间的排放率被认为是一个单独的分析案例，如果没有显着差异，则从进一步分析中将其排除。 4.我们观察到学习期间活动变化的两个主要类别，我们称之为学习选择性和学习依赖。有学习选择性的病例显示出活动的显着变化，因为猴子获悉了一种新型IS所指示的扫视，但在熟悉IS的试验中没有明显的调节作用。在熟悉的IS的试验中，许多这些细胞实际上没有活性。但是，当使用新型IS进行测试时，它们最初显示出戏剧性的调制。正如猴子在IS实验中观察到的那样，随着猴子选择可靠性更高的正确扫视镜（或靶标），调节作用通常会逐渐降低，直到细胞再次相对未受调节为止。这些细胞通常保持相对失活，直到猴子受到挑战以开始学习另一个新的刺激-反应关联。在所有任务期间都观察到学习选择性活动，在经过适当测试的186个SEF细胞中，有33个（18％）在一个或多个任务期间显示了学习选择性活动。（摘要截断了400个单词）

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