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首页> 外文期刊>Journal of Neurophysiology >Responses and afferent pathways of superficial and deeper c(1)-c(2) spinal cells to intrapericardial algogenic chemicals in rats.
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Responses and afferent pathways of superficial and deeper c(1)-c(2) spinal cells to intrapericardial algogenic chemicals in rats.

机译：浅层和较深的c（1）-c（2）脊髓细胞对大鼠心包内促成化学物质的反应和传入途径。

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Electrical stimulation of vagal afferents or cardiopulmonary sympathetic afferent fibers excites C(1)--C(2) spinal neurons. The purposes of this study were to compare the responses of superficial (depth <0.35 mm) and deeper C(1)--C(2) spinal neurons to noxious chemical stimulation of cardiac afferents and determine the relative contribution of vagal and sympathetic afferent pathways for transmission of noxious cardiac afferent input to C(1)--C(2) neurons. Extracellular potentials of single C(1)--C(2) neurons were recorded in pentobarbital anesthetized and paralyzed male rats. A catheter was placed in the pericardial sac to administer a mixture of algogenic chemicals (0.2 ml) that contained adenosine (10(-3) M), bradykinin, histamine, serotonin, and prostaglandin E(2) (10(-5) M each). Intrapericardial chemicals changed the activity of 20/106 (19%) C(1)--C(2) spinal neurons in the superficial laminae, whereas 76/147 (52%) deeper neurons responded to cardiac noxious input (P < 0.01). Of 96 neurons responsive to cardiac inputs, 48 (50%) were excited (E), 41 (43%) were inhibited (I), and 7 were excited/inhibited (E-I) by intrapericardial chemicals. E or I neurons responsive to intrapericardial chemicals were subdivided into two groups: short-lasting (SL) and long-lasting (LL) response patterns. In superficial gray matter, excitatory responses to cardiac inputs were more likely to be LL-E than SL-E neurons. Mechanical stimulation of the somatic field from the head, neck, and shoulder areas excited 85 of 95 (89%) C(1)--C(2) spinal neurons that responded to intrapericardial chemicals; 31 neurons were classified as wide dynamic range, 49 were high threshold, 5 responded only to joint movement, and no neuron was classified as low threshold. For superficial neurons, 53% had small somatic fields and 21% had bilateral fields. In contrast, 31% of the deeper neurons had small somatic fields and 46% had bilateral fields. Ipsilateral cervical vagotomy interrupted cardiac noxious input to 8/30 (6 E, 2 I) neurons; sequential transection of the contralateral cervical vagus nerve (bilateral vagotomy) eliminated the responses to intrapericardial chemicals in 4/22 (3 E, 1 I) neurons. Spinal transection at C(6)--C(7) segments to interrupt effects of sympathetic afferent input abolished responses to cardiac input in 10/10 (7 E, 3 I) neurons that still responded after bilateral vagotomy. Results of this study support the concept that C(1)-C(2) superficial and deeper spinal neurons play a role in integrating cardiac noxious inputs that travel in both the cervical vagal and/or thoracic sympathetic afferent nerves.
机译：迷走神经传入或心肺交感传入纤维的电刺激激发C（1）-C（2）脊髓神经元。这项研究的目的是比较浅层（深度<0.35毫米）和更深的C（1）-C（2）脊神经元对心脏传入神经的有害化学刺激的反应，并确定迷走神经和交感神经传入通路的相对贡献用于将有害的心脏传入输入传输到C（1）-C（2）神经元。戊巴比妥麻醉和瘫痪的雄性大鼠中记录了单个C（1）-C（2）神经元的细胞外电位。将导管置入心包囊中，以施用含腺苷（10（-3）M），缓激肽，组胺，5-羟色胺和前列腺素E（2）（10（-5）M）的促成生化学物质（0.2 ml）的混合物每）。心包内化学物质改变了浅表层中20/106（19％）C（1）-C（2）脊髓神经元的活性，而更深的76/147（52％）神经元对心脏有害输入有反应（P <0.01） 。在对心脏输入有反应的96个神经元中，有48个（50％）被兴奋（E），41个（43％）被抑制（I），有7个被心包内化学物兴奋/抑制（E-I）。对心包内化学物有反应的E或I神经元可分为两类：短时（SL）和长时（LL）反应模式。在浅层灰质中，对心脏输入的兴奋性反应比SL-E神经元更可能是LL-E。机械刺激来自头部，颈部和肩部区域的躯体区域激发了95个（89％）C（1）-C（2）脊髓神经元，它们对心包内化学物质有反应; 31个神经元被分类为宽动态范围，49个为高阈值，5个仅对关节运动作出反应，没有神经元被分类为低阈值。对于浅层神经元，有53％的人具有较小的躯体视野，有21％的人具有双侧视野。相比之下，深层神经元中有31％具有较小的躯体视野，而46％具有双侧视野。同侧子宫颈迷走神经切断术中断了对8/30（6 E，2 I）神经元的心脏有害输入;对侧子宫颈迷走神经的连续横断（双侧迷走神经切除术）消除了4/22（3 E，1 I）神经元对心包内化学物质的反应。在C（6）-C（7）处进行脊髓横切以中断交感传入输入的影响，消除了在10/10（7 E，3 I）个神经元中仍对双侧迷走神经切断后有反应的对心脏输入的反应。这项研究的结果支持这样的概念，即C（1）-C（2）浅层和较深的脊髓神经元在整合在颈迷走神经和/或胸交感神经传入神经中传播的心脏有害输入中发挥作用。

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