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首页> 外文期刊>Journal of Neurophysiology >Multiple components of ipsilaterally evoked inhibition in the inferior colliculus.
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Multiple components of ipsilaterally evoked inhibition in the inferior colliculus.

机译：下丘的同侧诱发抑制的多种成分。

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摘要

The central nucleus of the inferior colliculus (ICc) receives a large number of convergent inputs that are both excitatory and inhibitory. Although excitatory inputs typically are evoked by stimulation of the contralateral ear, inhibitory inputs can be recruited by either ear. Here we evaluate ipsilaterally evoked inhibition in single ICc cells in awake Mexican free-tailed bats. The principal question we addressed concerns the degree to which ipsilateral inhibition at the ICc suppresses contralaterally evoked discharges and thus creates the excitatory-inhibitory (EI) properties of ICc neurons. To study ipsilaterally evoked inhibition, we iontophoretically applied excitatory neurotransmitters and visualized the ipsilateral inhibition as a gap in the carpet of background activity evoked by the transmitters. Ipsilateral inhibition was seen in 86% of ICc cells. The inhibition in most cells had both glycinergic and GABAergic components that could be blocked by the iontophoretic application of bicuculline and strychnine. In 80% of the cells that were inhibited, the ipsilateral inhibition and contralateral excitation were temporally coincident. In many of these cells, the ipsilateral inhibition suppressed contralateral discharges and thus generated the cell's EI property in the ICc. In other cells, the ipsilateral inhibition was coincident with the initial portion of the excitation, but the inhibition was only 2-4 ms in duration and suppressed only the first few contralaterally evoked discharges. The suppression was so slight that it often could not be detected as a decrease in the spike count generated by increasing ipsilateral intensities. Twenty percent of the cells that expressed inhibition, however, had inhibitory latencies that were longer than the excitatory latencies. In these neurons, the inhibition arrived too late to suppress most or any of the discharges. Finally, in the majority of cells, the ipsilateral inhibition persisted for tens of milliseconds beyond the duration of the signal that evoked it. Thus ipsilateral inhibition has multiple components and one or more of these components are typically evoked in ICc neurons by sound received at the ipsilateral ear.
机译：下丘脑（ICc）的中心核接收大量收敛性和兴奋性输入。尽管通常通过对侧耳朵的刺激来激发兴奋性输入，但是任何一只耳朵都可以吸收抑制性输入。在这里，我们评估了清醒的墨西哥自由尾蝙蝠的单个ICc细胞中同侧诱发的抑制作用。我们解决的主要问题涉及在ICc上同侧抑制抑制对侧诱发放电的程度，从而产生ICc神经元的兴奋性抑制（EI）特性。为了研究同侧诱发的抑制作用，我们用离子电渗法应用了兴奋性神经递质，并将同侧抑制可视化为由传质引起的背景活动的障碍。在86％的ICc细胞中观察到同侧抑制。在大多数细胞中，抑制作用都具有甘氨酸和GABA成分，而双瓜氨酸和士的宁可以通过离子电渗疗法来阻断。在80％被抑制的细胞中，同侧抑制和对侧兴奋在时间上是一致的。在许多这些细胞中，同侧抑制作用抑制了对侧放电，因此在ICc中产生了细胞的EI特性。在其他细胞中，同侧抑制与激发的初始部分重合，但是抑制的持续时间仅为2-4 ms，并且仅抑制了前几个对侧诱发的放电。这种抑制作用是如此之小，以致于由于同侧强度的增加而导致的尖峰计数的减少通常无法被检测到。然而，表达抑制的细胞中有20％的抑制潜伏期比兴奋性潜伏期长。在这些神经元中，抑制作用为时已晚，无法抑制大部分或任何放电。最后，在大多数细胞中，同侧抑制作用持续超过诱发它的信号持续时间超过数十毫秒。因此，同侧抑制具有多个成分，并且通常通过在同侧耳处接收到的声音在ICc神经元中诱发这些成分中的一个或多个。

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