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首页> 外文期刊>Journal of Neurophysiology >Kinematic coordinates in which motor cortical cells encode movement direction.
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Kinematic coordinates in which motor cortical cells encode movement direction.

机译：运动皮层细胞编码运动方向的运动学坐标。

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摘要

During goal-directed reaching in primates, a sensorimotor transformation generates a dynamical pattern of muscle activation. Within the context of this sensorimotor transformation, a fundamental question concerns the coordinate systems in which individual cells in the primary motor cortex (MI) encode movement direction. This article develops a mathematical framework that computes, as a function of the coordinate system in which an individual cell is hypothesized to operate, the spatial preferred direction (pd) of that cell as the arm configuration and hand location vary. Three coordinate systems are explicitly modeled: Cartesian spatial, shoulder-centered, and joint angle. The computed patterns of spatial pds are distinct for each of these three coordinate systems, and experimental approaches are described that can capitalize on these differences to compare the empirical adequacy of each coordinate hypothesis. One particular experiment involving curved motion was analyzed from this perspective. Out of the three coordinate systems tested, the assumption of joint angle coordinates best explained the observed cellular response properties. The mathematical framework developed in this paper can also be used to design new experiments that are capable of disambiguating between a given set of specified coordinate hypotheses.
机译：在灵长类动物的目标定向到达过程中，感觉运动转换产生肌肉激活的动态模式。在这种感觉运动转换的背景下，一个基本问题涉及坐标系，在该坐标系中，主运动皮层（MI）中的各个单元编码运动方向。本文开发了一种数学框架，该数学框架根据假设单个细胞在其中运行的坐标系来计算该细胞在手臂配置和手部位置变化时的空间偏好方向（pd）。明确建模了三个坐标系：笛卡尔空间坐标系，肩部居中坐标和关节角度。对于这三个坐标系中的每个坐标系，空间pds的计算模式是不同的，并且描述了可以利用这些差异来比较每个坐标假设的经验充足性的实验方法。从这个角度分析了一个涉及弯曲运动的特殊实验。在测试的三个坐标系中，关节角坐标的假设最能解释观察到的细胞反应特性。本文开发的数学框架还可以用于设计新实验，这些实验能够消除给定的一组指定坐标假设之间的歧义。

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