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首页> 外文期刊>Journal of Neurophysiology >Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
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Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.

机译：通过皮肤机械伤害感受器的空间种群编码有害性压痕进入大鼠皮肤的位置和强度。

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摘要

The ability of a spatial population of cutaneous, Adelta, and C mechano-nociceptors to encode the location and intensity of a noxious, cutaneous indentation was examined using an isolated preparation in a rat model. Skin and its intact innervation were harvested from the medial thigh of the rat hindlimb and placed in a dish, with the corium side down, containing synthetic interstitial fluid. The margins of the skin were coupled to an apparatus that could stretch and apply compression to the skin. The skin was suspended on top of a deformable platform whose bulk, nonlinear, compressive compliance emulated that found in vivo. The isolated preparation facilitated examination of the spatial population response by eliminating the nonlinear geometry and inhomogeneous compressive compliance present in-vivo. Spatial population responses (SPR) were formed from recordings of single neurons that were stimulated by compressing the skin with an indenter (flat cylinder, 3-mm diam) at discrete intervals from the center of their receptive fields. SPR were composed of the neural responses (z axis) at each indentation location (x, y plane), and were analyzed quantitatively using nonlinear regression to fit an equation of a Gaussian surface. Both Adelta and C SPR accurately encoded the location and intensity of noxious indentation. The intensity of the stimulus was encoded in the peak neural response of the SPR, which had a nonlinear relationship to the compressive force. The location of the stimulus was encoded in the x, y position of the peak of the SPR. The position of the peak remained constant with increasing magnitudes of compressive force. The overall form of the SPR also remained constant with changes of compressive load, suggesting a possible role for encoding in the SPR some aspects of shape of a noxious stimulus.
机译：使用大鼠模型中的分离制剂检查了皮肤，Adelta和C型机械伤害感受器的空间种群编码有害的皮肤压痕的位置和强度的能力。从大鼠后肢的大腿内侧收获皮肤及其完整的神经，将其放入皮质的培养皿中，使皮质侧朝下，其中含有合成的组织液。皮肤的边缘与可以拉伸并向皮肤施加压力的装置相连。将皮肤悬浮在可变形平台的顶部，该平台可模拟体内发现的大量，非线性，压缩顺应性。孤立的准备工作消除了体内存在的非线性几何形状和不均匀的压缩顺应性，从而促进了空间种群响应的检查。空间种群响应（SPR）是由单个神经元的记录形成的，这些记录是通过以一个压头（扁平圆柱体，直径3 mm）从压迫器的感受野区域中心以不连续的间隔挤压皮肤来刺激的。 SPR由每个压痕位置（x，y平面）的神经响应（z轴）组成，并使用非线性回归进行定量分析以拟合高斯曲面的方程。 Adelta和C SPR均可准确编码有害压痕的位置和强度。刺激的强度编码在SPR的峰值神经反应中，该反应与压力呈非线性关系。刺激的位置编码在SPR峰的x，y位置。峰的位置随着压力的增加而保持恒定。 SPR的整体形式也随着压缩负载的变化而保持不变，这表明在有害刺激形状的某些方面编码可能在SPR中发挥作用。

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