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首页> 外文期刊>Journal of Neurophysiology >Asymmetric propagation of spreading depression along the anteroposterior axis of the cerebral cortex in mice.
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Asymmetric propagation of spreading depression along the anteroposterior axis of the cerebral cortex in mice.

机译：小鼠沿着大脑皮层前后轴不对称地传播抑郁症。

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摘要

The purpose of this study was to ascertain whether or not spreading depression (CSD) propagates symmetrically along the anteroposterior axis of the cortex of mice, and to determine where CSD should be elicited to achieve a uniform exposure of the cortex to this phenomenon. Experiments were performed in halothane-anesthetized mice, with three different locations aligned 1.5 mm from the midline used for either KCl elicitation of CSD or the recording of its propagation. Our results demonstrated that, at least in the mouse cortex, CSD propagated much more effectively from posterior to anterior regions than in the opposite direction. This feature was due to a different efficacy of propagation in the two opposite directions, and not to a reduced susceptibility of occipital regions to CSD elicitation. Heterogeneous CSD propagation constitutes a potential pitfall for neurochemical studies of post-CSD changes in mice, as brain tissue samples collected for this purpose should be uniformly exposed to CSD. Occipital sites for CSD induction are clearly optimal for this purpose. If CSD propagation is confirmed to be more effective from posterior to anterior regions in other species, this may be relevant to the pathophysiology of classical migraine because the most frequent aura symptoms (i.e., visual disturbances) originate in the occipital cortex.
机译：这项研究的目的是确定扩散性抑郁症（CSD）是否沿小鼠皮质的前后轴对称传播，并确定应在何处诱发CSD以使皮质均匀地暴露于这种现象。在氟烷麻醉的小鼠中进行实验，三个不同的位置与中线相距1.5 mm，用于KCl诱发CSD或记录其传播。我们的结果表明，至少在小鼠皮质中，CSD从后部到前部的传播要比相反方向更有效。该特征是由于在两个相反方向上传播的功效不同，而不是由于枕骨区域对CSD诱发的敏感性降低了。 CSD异质繁殖构成了小鼠CSD后变化的神经化学研究的潜在陷阱，因为为此目的收集的脑组织样本应均匀暴露于CSD。显然，用于CSD诱导的枕骨部位是最佳的。如果已确认CSD从其他物种的后部到前部区域传播更有效，则这可能与经典偏头痛的病理生理有关，因为最常见的先兆症状（即视觉障碍）起源于枕叶皮层。

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