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首页> 外文期刊>Journal of Neurophysiology >Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb.
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Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb.

机译：大鼠嗅球肾小球层中神经元的电生理。

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摘要

In the mammalian olfactory bulb, glomeruli are surrounded by a heterogeneous population of interneurons called juxtaglomerular neurons. As they receive direct input from olfactory receptor neurons and connect with mitral cells, they are involved in the initial stages of olfactory information processing, but little is known about their detailed physiological properties. Using whole cell patch-clamp techniques, we recorded from juxtaglomerular neurons in rat olfactory bulb slices. Based on their response to depolarizing pulses, juxtaglomerular neurons could be divided into two physiological classes: bursting and standard firing. When depolarized, the standard firing neurons exhibited a range of responses: accommodating, nonaccommodating, irregular firing, and delayed to firing patterns of action potentials. Although the firing pattern was not rigorously predictive of a particular neuronal morphology, most short axon cells fired accommodating trains of action potentials, while most delayed to firing cells were external tufted cells. In contrast to the standard firing neurons, bursting neurons produced a calcium-channel-dependent low-threshold spike when depolarized either by current injection or by spontaneous or evoked postsynaptic potentials. Bursting neurons also could oscillate spontaneously. Most bursting cells were either periglomerular cells or external tufted cells. Based on their mode of firing and placement in the bulb circuit, these bursting cells are well situated to drive synchronous oscillations in the olfactory bulb.
机译：在哺乳动物的嗅球中，肾小球被称为近肾小球神经元的异质神经元包围。由于它们从嗅觉受体神经元接收直接输入并与二尖瓣细胞连接，因此它们参与了嗅觉信息处理的初始阶段，但对其详细的生理特性知之甚少。使用全细胞膜片钳技术，我们记录了大鼠嗅球切片中的近肾小球神经元。根据它们对去极化脉冲的响应，可以将近肾小球神经元分为两个生理类别：爆裂和标准击发。当去极化时，标准的发射神经元表现出一系列反应：适应性，非适应性，不规则性发射和延迟到动作电位的发射模式。尽管放电模式不能严格预测特定的神经元形态，但大多数短轴突细胞均会发射一系列动作电位，而延迟到发射细胞中的大多数是外部簇状细胞。与标准的发射神经元相反，当通过电流注入或通过自发或诱发的突触后电位去极化时，爆发的神经元产生依赖于钙通道的低阈值尖峰。爆发的神经元也可能自发振荡。大多数破裂细胞是肾小球周围细胞或外部簇状细胞。根据它们在灯泡电路中的发射和放置模式，这些爆裂电池的位置可以很好地驱动嗅觉灯泡中的同步振荡。

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