Hydrogen and hydration of DNA and RNA oligonucleotides.

Sundaralingam M; Pan B

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Hydrogen and hydration of DNA and RNA oligonucleotides.

机译：DNA和RNA寡核苷酸的氢和水合。

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In this paper, hydrogen bonding interaction and hydration in crystal structures of both DNA and RNA oligonucleotides are discussed. Their roles in the formation and stabilization of oligonucleotides have been covered. Details of the Watson-Crick base pairs G.C and A.U in DNA and RNA are illustrated. The geometry of the wobble (mismatched) G.U base pairs and the cis and almost trans conformations of the mismatched U.U base pairs in RNA is described. The difference in hydration of the Watson-Crick base pairs G.C, A.U and the wobble G.U in different sequences of codon-anticodon interaction in double helical molecules are indicative of the effect of hydration. The hydration patterns of the phosphate, the 2'-hydroxyl groups, the water bridges linking the phosphate group, N7 (purine) and N4 of Cs or O4 of Us in the major groove, the water bridges between the 2'-hydroxyl group and N3 (purine) and O2 (pyrimidine) in the minor groove are discussed.

机译：在本文中，讨论了DNA和RNA寡核苷酸晶体结构中的氢键相互作用和水合。已经涵盖了它们在寡核苷酸形成和稳定中的作用。说明了DNA和RNA中Watson-Crick碱基对G.C和A.U的详细信息。描述了摆动（错配）的G.U碱基对的几何形状以及RNA中错配的U.U碱基对的顺式和几乎反式构象。沃森-克里克碱基对G.C，A.U和摆动G.U在双螺旋分子中不同密码子-反密码子相互作用序列的水合作用差异表明了水合作用。磷酸盐，2'-羟基的水合模式，在主要凹槽中连接磷酸基，Us的Cs或O4的N7（嘌呤）和N4的水桥，2'-羟基和讨论了小沟中的N3（嘌呤）和O2（嘧啶）。

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2002年第3期|共10页
作者
Sundaralingam M; Pan B;
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原文格式 PDF
正文语种 eng
中图分类生物化学;生物物理学;
关键词
hydration; Unit; RNA; Base; NOS;

机译：水化;单位;RNA;碱基;NOS;

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专利

1. Hydrogen and hydration of DNA and RNA oligonucleotides. [J] . Sundaralingam M, Pan B Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2002,第3期

机译：DNA和RNA寡核苷酸的氢和水合。
2. Sensitivity of hydrogen bonds of DNA and RNA to hydration, as gauged by (1)supercript stop (1)J(NH) measurements in ethanol-water mixtures [J] . Manalo MN, Kong XM, LiWang A Journal of Biomolecular NMR . 2007,第4期

机译：DNA和RNA氢键对水合的敏感性，通过乙醇-水混合物中的（1）上标终止（1）J（NH）测量来衡量
3. Sensitivity of hydrogen bonds of DNA and RNA to hydration, as gauged by 1 J NH measurements in ethanol–water mixtures [J] . Marlon N. Manalo, Xiangming Kong, Andy LiWang Journal of Biomolecular NMR . 2007,第4期

机译：1 NH 在乙醇-水混合物中的测量结果表明，DNA和RNA的氢键对水合作用的敏感性
4. Construction of oligonucleotide-RNase H conjugates using 2’-O -diazirine modified oligonucleotides. [C] . Yuta Sugihara, Haruka Hirose, Soichi Tatsumi 日本化学会春季年会講演予稿集 . 2018

机译：使用2'-Odiazirine改性寡核苷酸构建寡核苷酸-RNase H缀合物。
5. Structural bioinformatics of cyclic AMP-DNA binding sites and molecular dynamics simulations of DNA oligonucleotides. [D] . Thayer, Kelly Marie. 2004

机译：环状AMP-DNA结合位点的结构生物信息学和DNA寡核苷酸的分子动力学模拟。
6. Circular RNA oligonucleotides. Synthesis nucleic acid binding properties and a comparison with circular DNAs. [O] . S Wang, E T Kool 1994

机译：环状RNA寡核苷酸。合成核酸结合特性以及与环状DNA的比较。
7. Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs. [O] . Wang, S, Kool, E T 1994

机译：环状RNA寡核苷酸。合成，核酸结合特性以及与环状DNA的比较。

Hydrogen and hydration of DNA and RNA oligonucleotides.

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