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首页> 外文期刊>Journal of Neuroscience Methods >A combined behavioral-physiological method for the assessment of thermal sensibility in the rat.
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A combined behavioral-physiological method for the assessment of thermal sensibility in the rat.

机译：一种用于评估大鼠热敏感性的综合行为生理方法。

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摘要

A behavioral and physiological method has been developed to study thermal detection in the rat. Threshold temperatures signaling (1) disruption of a trained behavior (forelimb bar pressing) and (2) increased heart rate were determined using a gradually increasing thermal stimulus delivered to the hindlimb. Response thresholds for disruption of bar press activity (44.8 degrees C) and heart rate elevation (44.4 degrees C) were statistically equivalent. No differences in thresholds for either response end point were found between the left and right hindlimbs, thus validating the consistency of the technique and reproducibility of the stimulus delivery device during test periods of 3-4 weeks. Advantages of the method include the use of two independent end points that are determined objectively, performance criteria that do not rely upon motor responses from the stimulated limb and the use of quantitative descriptors that enables comparisons to be made between different test groups. The method combines behavior with cardiovascular and somatosensory function in a way that can be used for the assessment of spinal and supraspinal pathways involved in thermal detection in the unanesthetized, behaviorally active rat.
机译：已经开发出一种行为和生理方法来研究大鼠中的热检测。使用传递到后肢的逐渐增加的热刺激来确定阈值温度信号，该信号指示（1）训练行为的中断（前肢按压）和（2）心率增加。压杆活动中断（44.8摄氏度）和心率升高（44.4摄氏度）的响应阈值在统计学上相等。在左后肢和右后肢之间未发现任何响应终点的阈值差异，因此验证了该技术的一致性以及在3-4周的测试期间刺激传递设备的可重复性。该方法的优点包括：使用两个客观确定的独立终点;不依赖于受刺激肢体的运动反应的性能标准;以及使用定量描述符，从而可以在不同测试组之间进行比较。该方法将行为与心血管和体感功能相结合，可用于评估未麻醉，行为活跃的大鼠的热检测所涉及的脊髓和脊髓上途径。

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