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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >The 'interceptor' properties of chlorophyllin measured within the three-component system: Intercalator-DNA-chlorophyllin
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The 'interceptor' properties of chlorophyllin measured within the three-component system: Intercalator-DNA-chlorophyllin

机译：在三组分系统中测得的叶绿素的“受体”性质：Intercalator-DNA-chlorophyllin

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摘要

In aqueous solutions, in the presence of double-stranded DNA, chlorophyllin (CHL) forms complexes with each of the three DNA intercalators: acridine orange (AO), quinacrine mustard (QM), and doxorubicin (DOX). The evidence for these interactions was obtained by measurement changes in the absorption and fluorescence spectra of the mixtures containing DNA and intercalators during titration with CHL. A model of simple competition between DNA and CHL for the intercalator was used to define the measured interactions. The concentrations of the complexes estimated based on this model were consistent with the concentrations obtained by actual measurement of the absorption spectra. The present data provide further support for the role of cblorophyllin as an "interceptor" that may neutralize biological activity of aromatic compounds including mutagens and antitumor drugs. (c) 2006 Elsevier B.V All rights reserved.
机译：在水溶液中，在双链DNA的存在下，叶绿素（CHL）与三种DNA嵌入剂（forms啶橙（AO），奎纳克芥菜（QM）和阿霉素（DOX））形成复合物。这些相互作用的证据是通过在CHL滴定过程中测量含有DNA和嵌入剂的混合物的吸收光谱和荧光光谱的变化而获得的。 DNA和CHL之间对于嵌入剂的简单竞争模型用于定义所测量的相互作用。基于该模型估算的复合物浓度与通过实际测量吸收光谱获得的浓度一致。本数据进一步提供了叶绿素作为“中和剂”的作用的支持，该中和剂可中和包括诱变剂和抗肿瘤药在内的芳族化合物的生物活性。 （c）2006 Elsevier B.V保留所有权利。

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