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首页> 外文期刊>Journal of Neuroscience Methods >Imaging brain activity in conscious animals using functional MRI.
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Imaging brain activity in conscious animals using functional MRI.

机译：使用功能性MRI对意识动物的脑部活动进行成像。

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Functional magnetic resonance imaging (fMRI) in humans has helped improve our understanding of the neuroanatomical organization of behavior. Unfortunately, fMRI in animal studies has not kept pace with the human work. Experiments are limited because animals must be anesthetized to prevent motion artifacts, precluding most studies involving neuroimaging of brain activity during behavior. The present study tested a newly developed head and body holder for performing fMRI in fully conscious animals. Significant changes in signal intensities were observed in the somatosensory cortex of conscious rats in response to electrical shock of the hindpaw. These changes in evoked signal ranged between 4 and 19% and were accompanied by significant increases in local cerebral blood flow. The fMRI study was performed with a 2.0-Tesla spectrometer. Using this non-invasive method of imaging brain activity in conscious animals, it is now possible to perform developmental studies in animal models of neurological and psychiatric disorders.
机译：人类的功能性磁共振成像（fMRI）帮助提高了我们对行为的神经解剖学组织的了解。不幸的是，动物研究中的功能磁共振成像技术未能跟上人类工作的步伐。实验是有限的，因为必须对动物进行麻醉以防止运动伪影，这阻止了大多数涉及行为期间大脑活动的神经成像的研究。本研究测试了一种新开发的头部和身体固定器，用于在完全清醒的动物中进行功能磁共振成像。在后足的电击中，在清醒大鼠的体感皮层中观察到信号强度的显着变化。这些诱发信号的变化范围在4％至19％之间，并伴有局部脑血流量的显着增加。 fMRI研究是使用2.0-Tesla光谱仪进行的。使用这种对意识动物脑活动进行成像的非侵入性方法，现在可以在神经和精神疾病的动物模型中进行发育研究。

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