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首页> 外文期刊>Journal of Neuroscience Methods >New technique for vagal nerve stimulation.
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New technique for vagal nerve stimulation.

机译：迷走神经刺激的新技术。

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INTRODUCTION: The vagus nerve travels in a neurovascular bundle with the carotid artery and internal jugular vein. The present study was designed to assess whether transvascular stimulation through the carotid artery of the dog can be used to directly stimulate the vagus nerve and increase parasympathetic tone. METHODS: In five anesthetized dogs, a steerable electrode catheter was positioned under fluoroscopic guidance in the right carotid artery in the mid neck via the femoral artery. Multipolar catheters were positioned transvenously through the femoral vein in the right atrium, across the tricuspid valve to record a His-bundle electrogram, and in the right ventricle. RESULTS: In all five animals, vagal nerve stimulation was successfully achieved with outputs ranging between 10 and 30 mA. Sinus cycle length increased from 473 +/- 113 ms at baseline to 894 +/- 315 ms (P < 0.025) during stimulation from the right carotid artery. There was an increase in the AH interval from 55 +/- 14 to 77 +/- 23 ms (P < 0.03), a shortening of the atrial effective refractory period from 136 +/- 8 to 126 +/- 6 ms (P < 0.01), and a fall in the systolic blood pressure from 135 +/- 20 to 117 +/- 20 mmHg (P < 0.005) with stimulation from the right carotid artery. A prolongation of the AV and VA block cycle lengths and the AV nodal effective refractory period was also noted with stimulation from the right carotid artery. Atrial fibrillation was not induced at baseline in any animal. During stimulation from the right carotid artery, atrial fibrillation was induced in three of five animals and persisted for the duration of stimulation from the right carotid artery. CONCLUSION: Cardiac parasympathetic stimulation can be achieved by positioning a catheter in the neurovascular bundle in the neck adjacent to the vagus nerve with resultant effects on cardiac electrophysiology.
机译：简介：迷走神经与颈动脉和颈内静脉一起在神经血管束中传播。本研究旨在评估通过狗的颈动脉的经血管刺激是否可用于直接刺激迷走神经并增加副交感神经张力。方法：在五只麻醉的狗中，在荧光镜引导下，将可操纵电极导管通过股动脉置于颈中部右颈动脉中。将多极导管经股静脉经静脉放置在右心房中，穿过三尖瓣以记录His束电描记图，并在右心室中。结果：在所有五只动物中，迷走神经刺激均成功完成，输出范围为10到30 mA。在从右颈动脉进行刺激期间，窦周期长度从基线的473 +/- 113毫秒增加到了894 +/- 315毫秒（P <0.025）。 AH间隔从55 +/- 14毫秒增加到77 +/- 23毫秒（P <0.03），心房有效不应期从136 +/- 8毫秒缩短到126 +/- 6毫秒（P <0.01），并且由于右颈动脉的刺激，收缩压从135 +/- 20 mmHg降至117 +/- 20 mmHg（P <0.005）。在右颈动脉刺激下，AV和VA阻滞周期的延长以及AV淋巴结的有效不应期也延长了。任何动物在基线时均未诱发房颤。在从右颈动脉进行刺激的过程中，在五只动物中的三只中诱发了房颤，并持续了从右颈动脉进行刺激的持续时间。结论：通过将导管放置在迷走神经附近的颈部神经血管束中，可以实现心脏副交感神经刺激，从而对心脏电生理产生影响。

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