...
首页> 外文期刊>Journal of Neuroscience Methods >Photolysis of a newly synthesized caged glycine activates the glycine receptor of rat CNS neurons.
【24h】

Photolysis of a newly synthesized caged glycine activates the glycine receptor of rat CNS neurons.

机译:新合成的笼状甘氨酸的光解激活了大鼠中枢神经系统神经元的甘氨酸受体。

获取原文
获取原文并翻译 | 示例
           

摘要

The functions of 12 different newly synthesized caged glycines were examined on strychnine-sensitive glycine receptors on rat hypothalamic neurons using photochemical and physiological methods. Quantitative analysis of Cl- current induced by photolyzed glycines revealed N-[1-(2-nitrophenyl)ethylcarbonoxyl] glycine (N4-caged glycine) to be the most effectively photolyzed. The current amplitude induced by photolyzed N4-caged glycine was almost the same as that induced by normal glycine. We propose N-[1-(2-nitrophenyl)ethylcarbonoxyl] to be a useful photolabile moiety for new caged neurotransmitters.
机译:使用光化学和生理学方法,在大鼠下丘脑神经元上对士的宁敏感的甘氨酸受体上检测了12种新合成的笼状甘氨酸的功能。通过光解甘氨酸诱导的Cl电流的定量分析显示,N- [1-(2-硝基苯基)乙基羰氧基]甘氨酸(N4笼蔽的甘氨酸)是最有效的光解方法。 N4笼罩的光解甘氨酸诱导的电流幅度与正常甘氨酸诱导的电流幅度几乎相同。我们建议N- [1-(2-硝基苯基)乙基羰基氧基]是新的笼状神经递质的有用的光不稳定部分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号