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首页> 外文期刊>Journal of Neuroscience Methods >Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging.
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Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging.

机译：使用功能磁共振成像直接比较人类和非人类灵长类动物的视觉皮层激活。

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摘要

We report a technique for functional magnetic resonance imaging (fMRI) in an awake, co-operative, rhesus macaque (Macaca mulatta) in a conventional 1.5T clinical MR scanner, thus accomplishing the first direct comparison of activation in visual cortex between humans and non-human primates with fMRI. Activation was seen in multiple areas of striate and extra-striate visual cortex and in areas for motion, object and face recognition in the monkey and in homologous visual areas in a human volunteer. This article describes T1, T2 and T2* values for macaque cortex, suitable MR imaging sequences, a training schedule, stimulus delivery apparatus and restraining hardware for monkey fMRI using a conventional 19 cm knee coil. Much of our understanding of the functional organization of the primate brain comes from physiological studies in monkeys. Direct comparison between species using fMRI such as those described here will help us to relate the wealth of existing knowledge on the functional organization of the non-human primate brain to human fMRI.
机译：我们报告了一种在传统的1.5T临床MR扫描器中处于清醒，合作，恒河猴（猕猴）的功能性磁共振成像（fMRI）的技术，从而完成了人类与非人类在视觉皮层中激活的首次直接比较-人类灵长类动物与功能磁共振成像。在人类志愿者的猴子和同源视觉区域中，在纹状体和纹状体视觉皮层的多个区域以及在运动，物体和面部识别的区域中都看到了激活。本文介绍了猕猴皮层的T1，T2和T2 *值，合适的MR成像序列，训练时间表，刺激传递设备以及使用常规19 cm膝盖线圈的猴子fMRI的约束硬件。我们对灵长类动物大脑功能组织的大部分了解来自猴子的生理研究。使用功能磁共振成像对物种进行直接比较（如此处所述）将有助于我们将有关非人类灵长类动物大脑功能组织的大量现有知识与人类功能磁共振成像联系起来。

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