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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Effect of externally applied electrostatic fields on the surface topography of ceramide-enriched domains in mixed monolayers with sphingomyelin
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Effect of externally applied electrostatic fields on the surface topography of ceramide-enriched domains in mixed monolayers with sphingomyelin

机译：外加静电场对鞘磷脂结合单分子层中神经酰胺富集域表面形貌的影响

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摘要

Lipid and protein molecules anisotropically oriented at a hydrocarbon-aqueous interface configure a dynamic array of self-organized molecular dipoles. Electrostatic fields applied to lipid monolayers have been shown to induce in-plane migration of domains or phase separation in a homogeneous system. In this work, we have investigated the effect of externally applied electrostatic fields on the distribution of the condensed ceramide-enriched domains in mixed monolayers with sphingomyelin. In these monolayers, the lipids segregate in different phases at all pressures. This allows analyzing by epifluorescence microscopy the effect of the electrostatic field at all lateral pressure because coexistence of lipid domains in condensed state are always present. Our observations indicate that a positive potential applied to an electrode placed over the monolayer promotes a repulsion of the ceramide-enriched domains which is rather insensitive to the film composition, depends inversely on the lateral pressure and exhibits threshold dependence on the in-plane elasticity. (c) 2006 Elsevier B.V All rights reserved.
机译：在烃-水界面上各向异性取向的脂质和蛋白质分子构成了自组织分子偶极子的动态阵列。已显示施加到脂质单层的静电场在均一系统中诱导域的平面内迁移或相分离。在这项工作中，我们研究了外部施加的静电场对鞘磷脂与混合单分子层中浓缩的神经酰胺富集域的分布的影响。在这些单层中，脂质在所有压力下都以不同的相分离。这允许通过落射荧光显微镜分析在所有侧向压力下静电场的影响，因为脂质域始终以凝聚态共存。我们的观察表明，施加到置于单层上的电极的正电势促进了富含神经酰胺的区域的排斥，该排斥对膜组成相当不敏感，反过来取决于横向压力，并且表现出对面内弹性的阈值依赖性。 （c）2006 Elsevier B.V保留所有权利。

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