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首页> 外文期刊>Journal of Neuroscience Methods >Directly applied low intensity direct electric current enhances peripheral nerve regeneration in rats.
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Directly applied low intensity direct electric current enhances peripheral nerve regeneration in rats.

机译：直接施加低强度直流电流可增强大鼠周围神经的再生。

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摘要

The influence of direct electric stimulation on nerve regeneration was studied in a model of crush injury of the sciatic nerve of rats. Forty-three rats were used and distributed in four groups according to the procedure: (1) intact nerve, inactive circuit; (2) crush injury, inactive circuit; (3) intact nerve, active circuit; (4) crush injury, active circuit. The low intensity continuous current circuit (1 microA) was implanted in the lumbar region, the anode being fixed to the muscles proximally and the cathode below the nerve distally to the lesion site. The Sciatic Functional Index (SFI) was evaluated at weekly intervals for 3 weeks, the sciatic nerve being resected on the 21st day for histologic and morphometric studies. The SFI progressively improved and the average fiber nerve density recovered to a nearly normal value in Group 2 and increased in Group 4 compared with the control groups (1 and 3), but this was accompanied by a decreased average fiber nerve diameter. Both number and diameter of inter and intra-fascicular blood vessels increased in the stimulated nerves. We conclude that low intensity direct electric stimulation enhances nerve regeneration following a controlled nerve crush injury and increases blood supply by increasing number and diameter of vasa nervorum.
机译：在大鼠坐骨神经挤压伤模型中研究了直接电刺激对神经再生的影响。使用43只大鼠，并按以下程序分为四组：（1）完整的神经，无活动的回路; （2）压伤，电路无效; （3）神经完整，活动回路; （4）压伤，有源电路。低强度连续电流电路（1 microA）植入腰部区域，阳极固定在近端的肌肉上，阴极固定在病变部位的神经下方。每周评估坐骨神经功能指数（SFI），持续3周，并在第21天切除坐骨神经以进行组织学和形态计量学研究。与对照组（1和3）相比，第2组的SFI逐渐改善，平均纤维神经密度恢复到接近正常值，第4组增加，但伴有平均纤维神经直径的减小。在受刺激的神经中，束间和束内血管的数量和直径均增加。我们得出的结论是，低强度直接电刺激可控制神经挤压损伤，从而增强神经再生，并通过增加脉管脉络膜血管的数目和直径来增加血液供应。

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