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首页> 外文期刊>Journal of Neuroscience Methods >Increased extracellular dopamine in nucleus accumbens in response to unconditioned and conditioned aversive stimuli: studies using 1 min microdialysis in rats.
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Increased extracellular dopamine in nucleus accumbens in response to unconditioned and conditioned aversive stimuli: studies using 1 min microdialysis in rats.

机译：响应无条件和有条件的厌恶刺激，伏隔核中细胞外多巴胺增加：在大鼠中进行1分钟微透析的研究。

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摘要

Previous microdialysis studies measuring extracellular dopamine levels in response to unconditioned and conditioned aversive stimuli have used relatively long (e.g. 10 min) sample durations, such that more than one stimulus event occurred within a single dialysis sample. The present study used 1 min dialysate sampling to measure changes in dopamine levels in response to individual stimulus presentations. The changes evoked by mild footshock showed an initial enhancement from the first to the second presentation, after which there was a steady decline in the response over subsequent presentations. Compared to the responses to footshock alone, when the footshock was paired with an unfamiliar tone, there was no change in the response to the first stimulus presentation, but a significant augmentation of responses during subsequent presentations, giving weight to the view that dopamine is not involved in the learning per se, but rather in the processing of learned information. Whilst an unfamiliar tone had no measurable effect on extracellular dopamine levels, the same tone which had previously been paired with footshock evoked a significant increase in dopamine during the tone presentation, indicating that it is the aversive nature of the stimulus onset rather than the 'rewarding' nature of its offset which increases extracellular dopamine.
机译：先前的微透析研究测量了对无条件和有条件的厌恶刺激做出反应的细胞外多巴胺水平，使用了相对较长的时间（例如10分钟），因此单个透析样品中发生了多个刺激事件。本研究使用1分钟的透析液采样来测量多巴胺水平对个体刺激表现的反应。轻度的足底震颤引起的变化从第一次到第二次就诊均表现出最初的增强，此后与随后的就诊相比，反应持续下降。与仅对触电的反应相比，当触电与不熟悉的音调配对时，对第一个刺激表现的反应没有变化，但是在随后的表现中反应的反应显着增加，从而强调了多巴胺并非多巴胺的观点。涉及学习本身，而是处理所学信息。虽然陌生的语气对细胞外多巴胺水平没有可测量的影响，但以前与足部休克配对的相同语气在语气表现期间引起多巴胺的显着增加，表明这是刺激发作的厌恶性质，而不是“奖励”。它的抵消性质增加了细胞外多巴胺。

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