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首页> 外文期刊>Journal of Neuroscience Methods >Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation.
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Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation.

机译：过脉冲使用于皮层内神经刺激的活化的氧化铱膜降解。

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摘要

Microelectrodes using activated iridium oxide (AIROF) charge-injection coatings have been pulsed in cat cortex at levels from near-threshold for neural excitation to the reported in vitro electrochemical charge-injection limits of AIROF. The microelectrodes were subjected to continuous biphasic current pulsing, using an 0.4V (versus Ag|AgCl) anodic bias with equal cathodal and anodal pulse widths, for periods up to 7h at a frequency of either 50Hz or 100Hz. At charge densities of 3mC/cm(2), histology revealed iridium-containing deposits in tissue adjacent to the charge-injection sites and scanning electron microscopy of explanted electrodes revealed a thickened and poorly adherent AIROF coating. Microelectrodes pulsed at 2mC/cm(2) or less remained intact, with no histologic evidence of non-biologic deposits in the tissue. AIROF microelectrodes challenged in vitro under the same pulsing conditions responded similarly, with electrodes pulsed at 3mC/cm(2) showing evidence of AIROF delamination after only 100s of pulsing at 100Hz (10,000 pulses total), while electrodes pulsed at 2mC/cm(2) for 7h at 50Hz ( [Formula: see text] pulses total) showed no evidence of damage. In vitro electrochemical potential transient measurements in buffered physiologic saline indicate that polarizing the AIROF beyond the potential window for electrolysis of water (-0.6 to 0.8V versus Ag|AgCl) results in the observed degradation.
机译：在猫皮层中，已将使用活化的氧化铱（AIROF）电荷注入涂层的微电极脉冲化，脉冲强度从接近阈值（用于神经激发）到已报道的AIROF体外电化学电荷注入极限。使用具有相等的阴极和阳极脉冲宽度的0.4V（相对于Ag | AgCl）阳极偏压，对微电极进行连续的双相电流脉冲，在50Hz或100Hz的频率下持续7h。在3mC / cm（2）的电荷密度下，组织学显示邻近组织中电荷注入部位的组织中含有铱，沉积电极的扫描电子显微镜显示其涂层厚且粘附力差。以2mC / cm（2）或更低的频率脉冲的微电极保持完好无损，没有组织学证据表明组织中没有生物沉积物。在相同脉冲条件下体外挑战的AIROF微电极的响应也类似，以3mC / cm（2）脉冲的电极在100Hz脉冲仅100s（总共10,000个脉冲）后显示出AIROF分层的迹象，而以2mC / cm（2）脉冲的电极）在50Hz的频率下持续7h（总脉冲数），没有损坏迹象。在缓冲生理盐水中进行体外电化学电势瞬态测量表明，AIROF极化超过电解水的电势窗口（相对于Ag | AgCl为-0.6至0.8V）会导致观察到的降解。

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