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首页> 外文期刊>Journal of Neuroscience Methods >Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry.
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Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry.

机译：通过植入式无线电遥测法测量自由移动大鼠的皮质和海马癫痫样活动。

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摘要

Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform ictal and interictal activity following an acute injection of either 40 mg/kg pentylenetetrazole (PTZ) or 13.8 mg/kg kainic acid (KA) was investigated. The occurrence of spontaneous seizures was also monitored 5-8 weeks after administration of KA. The present study demonstrated a sensitive method for monitoring cortical EEG, hippocampal EEG and EMG short and long-term by implantable radiotelemetry in freely moving rats.
机译：植入式无线电遥测技术已用于测量皮层脑电图（EEG），运动能力，体温和心血管参数。这种技术可以从自由移动的动物获得高质量的数据，而无需外部设备的复杂性。本文侧重于通过同时皮层脑电图，海马（HC）脑电图和肌电图（EMG）对大鼠的癫痫样活动进行短期和长期监测的方法。手术后监测温度的昼夜节律（CRT），以估计手术后动物恢复的需要。评估了不同位置的EMG电极，以最大程度地减少伪影并提高灵敏度。研究了急性注射40 mg / kg的亚戊基四唑（PTZ）或13.8 mg / kg的海藻酸（KA）后癫痫样发作的发作和发作间活动的发生情况。在施用KA后5-8周还监测了自发性癫痫的发生。本研究表明了一种通过植入式无线电遥测法在自由移动大鼠中监测短期和长期皮层脑电图，海马脑电图和肌电图的灵敏方法。

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