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首页> 外文期刊>Journal of Neuroscience Methods >A perfused rat brain model maintaining the connection between the central and peripheral nervous systems.
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A perfused rat brain model maintaining the connection between the central and peripheral nervous systems.

机译：维持中枢神经系统和周围神经系统之间联系的灌注大鼠脑模型。

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We have developed a new perfused brain model in rats. In this model, the cerebral circulation is separated from the systemic circulation, while the connections between the central and peripheral nervous systems are preserved. After bilateral common carotid, external carotid and vertebral artery ligation, bilateral common carotid arteries were cannulated to infuse rinsed human type O red blood cells mixed with modified Ringer's solution. To drain cerebral venous blood, external jugular veins were cannulated. Normal electrocortical activities were observed on electroencephalograms (EEGs) for more than 1h after the beginning of the perfusion. Somatosensory evoked potentials (SEPs) were also recorded. Direct infusion of pentylenetetrazol (PTZ) into the brain induced epileptic discharges on the EEGs and active dilation of cerebral arterioles, which was accompanied by an increase in systemic blood pressure (BP). The present model, in which we can change cerebral blood flow (CBF) and/or cerebral metabolism without directly affecting the systemic circulation, will provide a new approach to brain research.
机译：我们开发了一种新的大鼠灌注脑模型。在此模型中，脑循环与体循环分开，而中枢神经系统和周围神经系统之间的连接得以保留。在双侧颈总动脉，颈外动脉和椎动脉结扎后，对双侧颈总动脉进行插管，以注入冲洗后的人O型红细胞，并与改良的林格氏液混合。为了排出脑静脉血，将颈外静脉插管。灌注开始后，脑电图（EEGs）观察到正常的皮层活动超过1小时。还记录了体感诱发电位（SEP）。将戊四氮（PTZ）直接注入脑中会诱发脑电图上的癫痫放电和脑小动脉的主动扩张，并伴有全身血压（BP）升高。我们可以在不直接影响全身循环的情况下改变脑血流量（CBF）和/或脑代谢的当前模型，将为脑研究提供一种新方法。

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