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首页> 外文期刊>Journal of Neuroscience Methods >A dual RF resonator system for high-field functional magnetic resonance imaging of small animals.
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A dual RF resonator system for high-field functional magnetic resonance imaging of small animals.

机译：双射频谐振器系统，用于对小动物进行高场功能磁共振成像。

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摘要

A new apparatus has been developed that integrates an animal restrainer arrangement for small animals with an actively tunable/detunable dual radio-frequency (RF) coil system for in vivo anatomical and functional magnetic resonance imaging of small animals at 4.7 T. The radio-frequency coil features an eight-element microstrip line configuration that, in conjunction with a segmented outer copper shield, forms a transversal electromagnetic (TEM) resonator structure. Matching and active tuning/detuning is achieved through fixed/variable capacitors and a PIN diode for each resonator element. These components along with radio-frequency chokes (RFCs) and blocking capacitors are placed on two printed circuit boards (PCBs) whose copper coated ground planes form the front and back of the volume coil and are therefore an integral part of the resonator structure. The magnetic resonance signal response is received with a dome-shaped single-loop surface coil that can be height-adjustable with respect to the animal's head. The conscious animal is immobilized through a mechanical arrangement that consists of a Plexiglas body tube and a head restrainer. This restrainer has a cylindrical holder with a mouthpiece and position screws to receive and restrain the head of the animal. The apparatus is intended to perform anatomical and functional magnetic resonance imaging in conscious animals such as mice, rats, hamsters, and marmosets. Cranial images acquired from fully conscious rats in a 4.7 T Bruker 40 cm bore animal scanner underscore the feasibility of this approach and bode well to extend this system to the imaging of other animals.
机译：已经开发出一种新的装置，该装置将用于小动物的动物约束装置与主动可调/可失谐的双射频（RF）线圈系统集成在一起，用于在4.7 T下对小动物进行体内解剖和功能磁共振成像。线圈具有八元素微带线配置，与分段的外部铜屏蔽一起形成横向电磁（TEM）谐振器结构。匹配和有源调谐/失谐是通过每个谐振器元件的固定/可变电容器和PIN二极管实现的。这些组件与射频扼流圈（RFC）和阻塞电容器一起放置在两个印刷电路板（PCB）上，这些印刷电路板的覆铜接地层构成了体积线圈的正面和背面，因此是谐振器结构的组成部分。可以通过相对于动物头部高度可调的圆顶形单回路表面线圈接收磁共振信号响应。有意识的动物通过由有机玻璃体管和头枕组成的机械装置固定。该约束器具有一个带有烟嘴的圆柱形固定器和定位螺钉，以接收和约束动物的头部。该设备旨在在有意识的动物（如小鼠，大鼠，仓鼠和mar猴）中执行解剖学和功能磁共振成像。在4.7 T布鲁克40厘米口径动物扫描仪中从完全清醒的大鼠获得的颅骨图像强调了这种方法的可行性，并且预示着该系统可以扩展到其他动物的成像。

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