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首页> 外文期刊>Journal of Neuroscience Methods >Avoiding spectral leakage in objective detection of auditory steady-state evoked responses in the inferior colliculus of rat using coherence.
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Avoiding spectral leakage in objective detection of auditory steady-state evoked responses in the inferior colliculus of rat using coherence.

机译：使用相干性在大鼠下丘的听觉稳态诱发反应的客观检测中避免频谱泄漏。

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摘要

Local field potentials (LFP) are bioelectric signals recorded from the brain that reflect neural activity in a high temporal resolution. Separating background activity from that evoked by specific somato-sensory input is a matter of great clinical relevance in neurology. The coherence function is a spectral coefficient that can be used as a detector of periodic responses in noisy environments. Auditory steady-state responses to amplitude-modulated tones generate periodic responses in neural networks that may be accessed by means of coherence between the stimulation signal and the LFP recorded from the auditory pathway. Such signal processing methodology was applied in this work to evaluate in vivo, anaesthetized Wistar rats, activation of neural networks due to single carrier sound stimulation frequencies, as well as to evaluate the effect of different modulating tones in the evoked responses. Our results show that an inappropriate choice of sound stimuli modulating frequencies can compromise coherenceanalysis, e.g. misleading conclusions due to mathematical artefact of signal processing. Two modulating frequency correction protocols were used: nearest integer and nearest prime number. The nearest prime number correction was successful in avoiding spectral leakage in the coherence analysis of steady-state auditory response, as predicted by Monte Carlo simulations.
机译：局部电场电势（LFP）是从大脑记录的生物电信号，以高时间分辨率反映神经活动。将背景活动与特定的体感输入所引起的活动分开，是神经病学与临床高度相关的问题。相干函数是一个频谱系数，可以用作嘈杂环境中周期性响应的检测器。对振幅调制音的听觉稳态响应会在神经网络中生成周期性响应，可以通过刺激信号和从听觉路径记录的LFP之间的相干性来访问周期性响应。此类信号处理方法已用于这项工作中，以评估体内麻醉的Wistar大鼠，由于单载波声音刺激频率引起的神经网络的激活，以及评估不同调制音调在诱发反应中的作用。我们的结果表明，不适当选择声音刺激调制频率会损害相干分析，例如由于信号处理的数学伪像而产生的误导性结论。使用了两种调制频率校正协议：最接近的整数和最接近的质数。正如蒙特卡洛模拟所预测的那样，最近的质数校正成功地避免了稳态听觉响应的相干分析中的频谱泄漏。

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