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首页> 外文期刊>Journal of Neuroscience Methods >Detrimental effects of halothane narcosis on damage after endothelin-1-induced MCAO.
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Detrimental effects of halothane narcosis on damage after endothelin-1-induced MCAO.

机译：氟烷麻醉对内皮素1诱导的MCAO损伤的有害作用。

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摘要

The influence of anaesthesia in experimental stroke research is controversial. We addressed this problem using the model of endothelin-1-induced occlusion of the middle cerebral artery (eMCAO). This model provided the opportunity to compare the infarct volumes of rats which were under halothane anaesthesia during eMCAO induction with the lesions of rats which were without anaesthesia during eMCAO. All animals were implanted with guide cannulae which allowed the induction of ischaemia in freely moving animals. For comparison, one group of animals was exposed to halothane during the induction of ischaemia. Seven days after eMCAO, the average infarct volume of halothane-anaesthetised rats was significantly larger than the lesion in freely moving animals. This difference was mainly due to increased cortical damage, whereas the striatum was much less influenced. The cortical infarct volume 21 days after induction of eMCAO under anaesthesia was significantly reduced compared to the infarct volume 7 days after eMCAO under anaesthesia. Our results indicate that halothane anaesthesia during eMCAO can cause a transient cortical increase in ischaemic infarct volume. The influence of volatile anaesthetics on ischaemic pathophysiology should be taken into consideration when preclinically testing potential neuroprotective drugs for clinical applications.
机译：麻醉在中风实验研究中的影响是有争议的。我们使用内皮素-1诱发的大脑中动脉阻塞模型（eMCAO）解决了这个问题。该模型提供了机会来比较在eMCAO诱导期间在氟烷麻醉下的大鼠的梗塞体积与在eMCAO期间没有麻醉的大鼠的病变。将所有动物植入引导套管，该引导套管允许在自由移动的动物中诱导局部缺血。为了进行比较，一组动物在诱导局部缺血期间暴露于氟烷中。 eMCAO后7天，氟烷麻醉的大鼠的平均梗塞体积明显大于自由活动动物的病变面积。这种差异主要是由于皮质损伤的增加，而纹状体受到的影响要小得多。与麻醉下eMCAO后7天的梗死体积相比，麻醉下eMCAO诱导后21天的皮质梗塞体积明显减少。我们的结果表明，在eMCAO期间进行氟烷麻醉可能会导致缺血性梗死体积的短暂皮质增加。在临床前对临床应用潜在的神经保护药物进行临床测试时，应考虑挥发性麻醉剂对缺血性病理生理的影响。

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