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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Ion hydration: Implications for cellular function, polyelectrolytes, and protein crystallization.
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Ion hydration: Implications for cellular function, polyelectrolytes, and protein crystallization.

机译：离子水合：对细胞功能，聚电解质和蛋白质结晶的影响。

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Only oppositely charged ions with matching absolute free energies of hydration spontaneously form inner sphere ion pairs in free solution [K.D.Collins, Ions from the Hofmeister series and osmolytes: effects on proteins in solution and in the crystallization process, Methods 34 (2004) 300-311.]. We approximate this with a Law of Matching Water Affinities which is used to examine the issues of (1) how ions are selected to be compatible with the high solubility requirements of cytosolic components; (2) how cytosolic components tend to interact weakly, so that association or dissociation can be driven by environmental signals; (3) how polyelectrolytes (nucleic acids) differ from isolated charges (in proteins); (4) how ions, osmolytes and polymers are used to crystallize proteins; and (5) how the "chelate effect" is used by macromolecules to bind ions at specific sites even when there is a mismatch in water affinity between the ion and the macromolecular ligands.
机译：只有具有匹配的绝对水合自由能的带相反电荷的离子才能在自由溶液中自发形成内球离子对[KDCollins，霍夫迈斯特系列和渗透压的离子：对溶液和结晶过程中蛋白质的影响，方法34（2004）300- 311.]。我们用匹配的水亲和力定律对此进行近似，该定律用于研究以下问题：（1）如何选择与细胞溶质组分的高溶解度要求兼容的离子; （2）胞质成分如何趋于弱相互作用，从而缔合或解离可由环境信号驱动; （3）聚电解质（核酸）与孤立电荷（在蛋白质中）有何不同; （4）离子，渗透液和聚合物如何使蛋白质结晶; （5）即使在离子与大分子配体之间水亲合力不匹配的情况下，大分子如何利用“螯合效应”在特定位置结合离子。

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