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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >A hand-over-hand diffusing model for myosin-VI molecular motors.
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A hand-over-hand diffusing model for myosin-VI molecular motors.

机译：肌球蛋白VI分子电动机的交接扩散模型。

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摘要

Single molecules of dimeric myosin-VI have been demonstrated to be able to move processively towards the pointed end of actin filament with a mean step size of approximately 36 nm. Here we present a hand-over-hand diffusing mechanism for this unidirectional movement. Based on this mechanism, its dynamical behaviors such as the step-size distribution, dwell-time distributions and mean dwell time at various ATP and ADP concentrations and under various loads are studied in detail. The calculated results show good agreement with previous experimental results. The processive movement of mutant myosin-V with its neck domains truncated to only one IQ motif can also be explained by using this hand-over-hand diffusing model.
机译：已证明二聚肌球蛋白-VI的单分子能够以约36 nm的平均步长向肌动蛋白丝的尖端前进。在这里，我们提出了一种用于这种单向运动的交接式扩散机构。基于这种机理，详细研究了其动力学行为，如在各种ATP和ADP浓度下以及在各种载荷下的步长分布，驻留时间分布和平均驻留时间。计算结果与以前的实验结果吻合良好。突变肌球蛋白-V的颈部结构域被截短为一个智商基序的过程性运动也可以通过使用这种移交手扩散模型来解释。

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