...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience Methods >Trial time warping to discriminate stimulus-related from movement-related neural activity
【24h】

Trial time warping to discriminate stimulus-related from movement-related neural activity

机译：试用时间扭曲将刺激相关的行为与运动相关的神经活动区分开来

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In tasks where different sensory, cognitive, and motor events are mixed in a sequence it is difficult to determine whether neural activity is related to any behavioral parameter. Here, we consider the case in which two alternative trial-alignment schemes correspond to two different neural representations, one stimulus-related and the other movement-related, using both simulations of neural activity and real recordings in the medial premotor areas during a multiple-interval tapping task called synchronization-continuation task (SCT). To discover whether neural responses are better aligned to sensory or motor events we introduce a family of trial-alignment time-warping functions indexed by a single parameter such that when the parameter takes the value 0 the trials are aligned to the stimulus and when the parameter takes the value 1 they are aligned to the movement. We then characterize neurons by the best-fitting alignment scheme (in the sense of maximum likelihood) under the assumption that the correct alignment would produce homogeneous trials without excess trial-to-trial variation. We use Bayes factors to determine the evidence in favor of sensory or motor neural alignments. The simulations revealed that the variability in neural responses and sequential motor outputs are key parameters to obtain appropriate warping results. In addition, the analysis on the activity of 500 neurons in the medial premotor areas of monkeys executing the SCT showed that most of the neural responses (54.2%) were aligned to the tapping movements instead of the stimuli used to drive the temporal behavior. ? 2012 Elsevier B.V.
机译：在将不同的感觉，认知和运动事件按顺序混合的任务中，很难确定神经活动是否与任何行为参数有关。在这里，我们考虑了以下两种情况：使用神经活动的模拟和运动前内侧区域的真实记录，两种替代性的试验对齐方式分别对应两种不同的神经表示，一种与刺激有关，另一种与运动有关。间隔敲击任务称为同步继续任务（SCT）。为了发现神经反应是否更好地适应感觉或运动事件，我们引入了一个由单个参数索引的试验对齐时间扭曲函数系列，以便当该参数取值为0时，将试验与刺激对齐，以及何时将参数与刺激对齐取值为1，表示它们与运动对齐。然后，我们假设最佳对齐方式（在最大可能性的意义上）以正确的对齐方式将产生同类试验而没有过多的试验间差异来表征神经元。我们使用贝叶斯因子来确定有利于感觉或运动神经排列的证据。仿真结果表明，神经反应和连续运动输出的变化是获得适当翘曲结果的关键参数。此外，对执行SCT的猴子内侧运动前区域中500个神经元活动的分析表明，大多数神经反应（54.2％）与敲击运动相对应，而不是与用来驱动时间行为的刺激相对应。 ？ 2012年Elsevier B.V.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号