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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Ground-based methods reproduce space-flight experiments and show that weak vibrations trigger microtubule self-organisation
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Ground-based methods reproduce space-flight experiments and show that weak vibrations trigger microtubule self-organisation

机译：地面方法重现了航天实验并显示出微弱的振动会触发微管的自组织

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摘要

The effect of weightlessness on physical and biological systems is frequently studied by experiments in space. However, on the ground, gravity effects may also be strongly attenuated using methods such as magnetic levitation and clinorotation. Under suitable conditions, in vitro preparations of microtubules, a major element of the cytoskeleton, self-organise by a process of reaction-diffusion: self-organisation is triggered by gravity and samples prepared in space do not self-organise. Here, we report experiments carried out with ground-based methods of clinorotation and magnetic levitation. The behaviour observed closely resembles that of the space-flight experiment and suggests that many space experiments could be carried out equally well on the ground. Using clinorotation, we find that weak vibrations also trigger microtubule self-organisation and have an effect similar to gravity. Thus, in some in vitro biological systems, vibrations are a countermeasure to weightlessness. (c) 2005 Elsevier B.V. All rights reserved.
机译：失重对物理和生物系统的影响经常通过太空实验来研究。但是，在地面上，重力影响也可以使用磁悬浮和倾斜旋转等方法大大减弱。在合适的条件下，体外制备的微管是细胞骨架的主要成分，它是通过反应扩散过程自组织的：自组织是由重力触发的，在太空中制备的样品不会自组织。在这里，我们报告用地面旋转和磁悬浮地面方法进行的实验。观察到的行为非常类似于太空飞行实验，并且表明许多太空实验可以在地面上同样好地进行。使用倾斜旋转，我们发现微弱的振动也会触发微管的自组织，并具有类似于重力的作用。因此，在某些体外生物系统中，振动是减轻失重的对策。 （c）2005 Elsevier B.V.保留所有权利。

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