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首页> 外文期刊>Journal of Neuroscience Methods >Novel oral drug administration in an animal model of neuroleptic therapy.
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Novel oral drug administration in an animal model of neuroleptic therapy.

机译：一种抗精神病药物治疗动物模型中的新型口服药物给药。

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A novel method of oral drug administration was used in a neuroleptic animal study. Seventy male Sprague-Dawley rats were randomly subdivided into four groups, which were treated with clozapine, haloperidol, diazepam or a vehicle solution (5% sucrose solution). Oral drug treatment was achieved by training the rats to drink the drug of choice mixed with five percent sucrose or vehicle solution from a syringe. Within 3-4 weeks the haloperidol group developed vacuous chewing movement, which did not disappear with discontinuation of the drug. Significant weight gain was observed for all drug groups in relation to the control group, whereas only the diazepam group showed a significant increase in response latency on the disengage test of sensorimotor function, which disappeared with drug withdrawal. A novel means of testing the motivational status showed that all drug-treated groups engaged in eating chocolate before grooming (t=11.69, p<0.001), whereas the control group showed no specific tendency towards either task. Furthermore, there was a significant delay in grooming for the haloperidol group compared to the other drug groups and controls. In conclusion, a novel method of oral drug administration with minimum stress was introduced that was sufficient to cause the described changes in behavioural parameters. Additionally, the combination of tests used provided an efficient discrimination between the behavioural effects of clozapine, haloperidol and diazepam in rodents.
机译：在精神安定性动物研究中使用了一种新型的口服药物给药方法。将70只雄性Sprague-Dawley大鼠随机分为四组，分别用氯氮平，氟哌啶醇，地西epa或溶媒溶液（5％蔗糖溶液）治疗。通过训练大鼠饮用与5％蔗糖或来自注射器的溶媒溶液混合的所选药物，可以实现口服药物治疗。在3-4周内，氟哌啶醇组出现了空腹咀嚼运动，但在停药后并未消失。与对照组相比，所有药物组均观察到体重显着增加，而只有地西epa组在感觉运动功能脱离试验中反应潜伏期显着增加，并随着停药而消失。一种测试动机状态的新颖方法表明，所有药物治疗组在梳理之前都在吃巧克力（t = 11.69，p <0.001），而对照组则没有表现出对任一项任务的具体倾向。此外，与其他药物组和对照组相比，氟哌啶醇组的梳理显着延迟。总之，介绍了一种具有最小压力的新型口服药物给药方法，该方法足以引起所描述的行为参数变化。此外，所用测试的组合可有效区分氯氮平，氟哌啶醇和地西epa在啮齿类动物中的行为效果。

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