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首页> 外文期刊>Journal of Neuroscience Methods >Abnormal slow wave mapping (ASWAM)--A tool for the investigation of abnormal slow wave activity in the human brain.
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Abnormal slow wave mapping (ASWAM)--A tool for the investigation of abnormal slow wave activity in the human brain.

机译：异常慢波映射（ASWAM）-用于调查人脑中异常慢波活动的工具。

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摘要

Slow waves in the delta and theta frequency range, normal signs of deactivated networks in sleep stages, are considered 'abnormal' when prominent in the waking state and when generated in circumscribed brain areas. Structural cortical lesions, e.g. related to stroke, tumors, or scars, generate focal electric and magnetic slow wave activity in the penumbra. Focal concentrations of slow wave activity exceeding those of healthy subjects have also been found in individuals suffering from psychiatric disorders without obvious structural brain damage. Hence, identification and mapping of abnormal slow wave activity might contribute to the investigation of cortical indications of psychopathology. Here I propose a method for abnormal slow wave mapping (ASWAM), based on a 5 min resting magnetoencephalogramm (MEG) and equivalent current dipole fitting to sources in the 1-4 Hz frequency band (delta) in anatomically defined cortical regions. The method was tested in a sample of 116 healthy subjects (59 males), with the aim to provide a basis for later comparison with patient samples. As to be expected, delta dipole density was low in healthy subjects. However, its distribution differed between genders with fronto-central>posterior dipole density in male and posterior dominance in female participants, which was not significantly related to either age or head size. Results suggest that this method allows the identification of ASWA, so that comparison against Z-scores from a larger normal control group might assist diagnostic purposes in patient groups. As specific distributions seem to reflect differences between genders, this should be considered also in the analysis of patient samples.
机译：当处于醒来状态且在外接大脑的区域中产生时，在睡眠阶段失活的网络的正常信号，即δ和θ频率范围内的慢波被视为“异常”。结构性皮损，例如与中风，肿瘤或疤痕有关的疾病在半影中产生局灶性的电和磁慢波活动。在患有精神疾病但没有明显的结构性脑损伤的个体中，也发现了慢波活动的焦点浓度超过健康受试者的水平。因此，异常慢波活动的识别和定位可能有助于研究精神病理学的皮质指征。在这里，我提出了一种异常慢波映射（ASWAM）的方法，该方法基于5分钟的静息脑磁图（MEG）和等效电流偶极子拟合到解剖学上定义的皮层区域中1-4 Hz频带（δ）中的源。该方法在116名健康受试者（59名男性）的样本中进行了测试，旨在为以后与患者样本的比较提供基础。可以预期，健康受试者的δ偶极子密度低。然而，其分布在男性中具有不同的性别，即男性的额中中心>后偶极子密度和女性参与者中的后偶极子密度，这与年龄或头部大小均无显着关系。结果表明，该方法可以鉴定ASWA，因此与来自较大的正常对照组的Z得分进行比较可能有助于患者组的诊断。由于具体分布似乎反映出性别之间的差异，因此在分析患者样本时也应考虑到这一点。

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