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首页> 外文期刊>Journal of Neuroscience Methods >1-Phenoxy-2-propanol is a useful anaesthetic for gastropods used in neurophysiology.
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1-Phenoxy-2-propanol is a useful anaesthetic for gastropods used in neurophysiology.

机译：1-苯氧基-2-丙醇是用于神经生理学的腹足动物的有用麻醉剂。

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摘要

Anaesthesia is often used in neurophysiological, surgical, and neuroanatomical protocols. Several anaesthetics, including magnesium chloride, volatiles (halothane, etc.), and barbiturates, have been used in gastropod neurobiology. 1-Phenoxy-2-propanol (PP) is another anaesthetic option that has not yet been used extensively. We provide an analysis of the neural, muscular and behavioural effects of PP in gastropods. PP eliminates action potentials and reduces muscular contraction force in Hermissenda crassicornis, and eliminates behavioural activity in Tritonia diomedea. Our results show these effects are reversible, with complete action potential recovery, at least partial muscular recovery, and full behavioural recovery. Survival after surgery in T. diomedea was longer with PP than without anaesthetic, and PP also reduced contraction during tissue fixation in Lymnaea stagnalis. Moreover, PP can be bath applied, has low toxicity, and is biodegradable. Thus, PP is an effective anaesthetic in three species of gastropods, and useful in neurophysiological dissection, surgical, and fixation protocols.
机译：麻醉常用于神经生理，外科和神经解剖学方案。在腹足动物的神经生物学中已使用了几种麻醉剂，包括氯化镁，挥发物（氟烷等）和巴比妥类。 1-苯氧基-2-丙醇（PP）是另一种尚未广泛使用的麻醉剂。我们提供了PP在腹足动物中的神经，肌肉和行为影响的分析。 PP消除了动作障碍，降低了Hermissenda crassicornis中的肌肉收缩力，并消除了Tritonia diomedea中的行为活动。我们的结果表明，这些作用是可逆的，可以完全恢复动作电位，至少可以部分恢复肌肉，并且可以完全恢复行为。使用PP的穿线虫手术后的存活时间比没有麻醉的更长，并且PP也减少了固定的阔叶林的收缩。此外，PP可以浴涂，毒性低，并且可生物降解。因此，PP是三种腹足动物的有效麻醉剂，可用于神经生理解剖，手术和固定方案。

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