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首页> 外文期刊>Journal of Neuroscience Methods >Structural simplexity of the brain.
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Structural simplexity of the brain.

机译：大脑的结构简单性。

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摘要

Simplexity is an emerging concept that expresses a possible complementary relationship between complexity and simplicity. The brain has been known as the most complex structure, and tremendous effort has been spent to study how it works. By understanding complex function of the brain, one can hope to unravel the mystery of its diseases and its biological systems. We propose herein an entropy-based framework for analysis of complexity with a particular application to the study of white matter changes of the human brain. In this analysis, the proposed approach takes into account both morphological structure and image intensity values of MRI scans to construct the complexity profiles of the brain. It has been realized that the quantity and spatial distribution of white matter changes play an important role in cognitive decline (i.e. dementia) and other neuropsychiatric disorders (i.e. multiple sclerosis, depression) as well as in other dementia disorders such as Alzheimers disease. Thus, the results can be utilized as a tool for automated quantification and comparison of various spatial distributions and orientations of age-related white matter changes where manual analysis is difficult and leads to different sensitivities for the respective MRI-based information of the brain.
机译：简单性是一个新兴的概念，表示复杂性和简单性之间可能的互补关系。大脑被认为是最复杂的结构，并且已经花费了巨大的努力来研究其工作原理。通过了解大脑的复杂功能，人们可以希望阐明其疾病及其生物系统的奥秘。我们在此提出一种基于熵的框架，用于分析复杂性，并将其特别应用于研究人脑的白质变化。在此分析中，提出的方法同时考虑了MRI扫描的形态结构和图像强度值，以构造大脑的复杂度曲线。已经认识到，白质变化的数量和空间分布在认知能力下降（即痴呆）和其他神经精神疾病（即多发性硬化症，抑郁）以及其他痴呆症例如阿尔茨海默氏病中起重要作用。因此，该结果可以用作自动定量和比较与年龄相关的白质变化的各种空间分布和方向的工具，在这些情况下，手动分析比较困难，并且导致大脑的各个基于MRI的信息具有不同的敏感性。

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