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首页> 外文期刊>Journal of Neuroscience Methods >Consistency of the auditory evoked response: The presence of aberrant responses and their effect on N100 localization
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Consistency of the auditory evoked response: The presence of aberrant responses and their effect on N100 localization

机译：听觉诱发反应的一致性：异常反应的存在及其对N100定位的影响

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摘要

The structure and distribution of the sources underlying the generation of evoked potentials (EPs) is often very complex. In an effort to improve localization accuracy of the auditory N100 (negative response occurring around 100. ms poststimulus) component, we analyzed 13 datasets of single-trial EPs obtained from normal subjects using an iterative independent component analysis procedure which allowed us to detect a clear N100 component in each single trial and to study gross changes in component morphology across trials. We found that single-trial N100 amplitude was most often negative in polarity, as expected, but occasionally exhibited a marked reversal to become positive. The average N100, however, showed the typical negative polarity, in all subjects.Based on this observation, we separated the processed single trials in two groups of typical and aberrant responses, and from each group, we computed a partial EP that was used to localize the underlying intracranial sources. Additionally, we localized the classical ensemble average EP. Before processing, the N100 sources were identified correctly in the primary auditory cortex in only four datasets, while after processing, all 13 datasets yielded correct localizations, and the confidence volume of the sources improved by about 80%. Further analysis demonstrated that in nine datasets the improvement was mostly due to the typical responses, while the aberrant responses had an antagonistic effect.Our results suggest that aberrant responses should not be included in source localizations, especially when EEG-based brain mapping is intended as a clinical tool.
机译：诱发电位（EPs）产生的来源的结构和分布通常非常复杂。为了提高听觉N100（在刺激后约100 ms发生负反应）组件的定位精度，我们使用迭代独立组件分析程序分析了从正常受试者获得的13个单项EP的数据集，这使我们能够检测到清晰的声音。每个单项试验中的N100成分，并研究整个试验中成分形态的总体变化。我们发现，如预期的那样，单次N100振幅的极性通常为负，但偶尔会出现明显的反转，变为正。然而，平均N100在所有受试者中均显示出典型的负极性。基于此观察结果，我们将经过处理的单次试验分为两组典型和异常反应，然后从每组中计算出部分EP，以用于定位潜在的颅内来源。此外，我们对古典合奏平均EP进行了本地化。在处理之前，仅在四个数据集中的主听皮层中正确识别了N100来源，而在处理之后，所有13个数据集均产生了正确的定位，并且来源的置信度提高了约80％。进一步的分析表明，在9个数据集中，改善主要归因于典型响应，而异常响应则具有拮抗作用。我们的结果表明，异常响应不应包括在源定位中，特别是当基于EEG的脑图定位为临床工具。

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