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首页> 外文期刊>Journal of Neuroscience Methods >An objective measurement of locomotion behavior for hemiparkinsonian cynomolgus monkeys.
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An objective measurement of locomotion behavior for hemiparkinsonian cynomolgus monkeys.

机译：客观测量半帕金森氏猕猴的运动行为。

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摘要

Both clinical rating scales and objective locomotion measurement are critical evaluation for primate models of Parkinson's disease. Video image analysis system which has been widely used for objective measurement of locomotion behavior for systemic models has rarely been applied to hemiparkinsonian primate model. In this study, a video image analysis system provided by Vigie Primates software was used to assess the locomotion behavior of MPTP hemi-lesioned parkinsonian cynomolgus monkeys by intracarotid infusion. Regardless the presence of only hemilateral abnormal movement, this video image analysis system was sensitive enough to demonstrate a significant difference between normal and MPTP hemi-lesioned animal on several aspects of motor behavior depicted by this software, including quantity of movement, duration spent in activity and count of burst activity. Specifically, a newly introduced ratio of duration/count for every type of movements was a sensitive parameter to objectively measure the changes of locomotion behavior in MPTP hemi-lesioned parkinsonian primates. As a result, the ratio of duration/count for the middle activity was decreased and the ratio of duration/count for the freezing activity was increased in MPTP hemi-lesioned animals, which correlated well with clinical rating scores. Our results support that video image analysis system would be a sensitive objective measurement of locomotion behavior for hemi-lesioned parkinsonian monkeys.
机译：临床评估量表和客观运动测量值都是对帕金森氏病灵长类动物模型的关键评估。广泛用于系统模型运动行为的客观测量的视频图像分析系统很少用于半帕金森氏灵长类动物模型。在这项研究中，使用由Vigie Primates软件提供的视频图像分析系统，通过颈动脉内输注评估了MPTP半病变帕金森氏猕猴的运动行为。无论仅存在半侧异常运动，此视频图像分析系统都足够灵敏，可以证明该软件描述的正常和MPTP半病变动物在运动行为的多个方面都有显着差异，包括运动量，活动时间和爆发活动的计数。具体而言，新引入的每种运动类型的持续时间/计数之比是一个敏感参数，可客观地测量MPTP半病变帕金森氏灵长类动物的运动行为变化。结果，在MPTP半病变动物中，中间活动的持续时间/计数的比率降低，而冷冻活动的持续时间/计数的比率增加，这与临床评分得分密切相关。我们的研究结果表明，视频图像分析系统将是对半病变帕金森氏猴的运动行为的敏感客观测量。

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