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首页> 外文期刊>Journal of Neuroscience Methods >Quantitative grey matter histological measures do not correlate with grey matter probability values from in vivo MRI in the temporal lobe.
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Quantitative grey matter histological measures do not correlate with grey matter probability values from in vivo MRI in the temporal lobe.

机译：定量灰质组织学测量与颞叶体内MRI的灰质概率值不相关。

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摘要

Voxel-based morphometry (VBM) is commonly used to study systematic differences in brain morphology from patients with various disorders, usually by comparisons with control subjects. It has often been suggested, however, that VBM is also sensitive to variations in composition in grey matter. The nature of the grey matter changes identified with VBM is still poorly understood. The aim of the current study was to determine whether grey matter histopathological measurements of neuronal tissue or gliosis influenced grey matter probability values that are used for VBM analyses. Grey matter probability values (obtained using both SPM5 and FSL-FAST) were correlated with neuronal density, and field fraction of NeuN and GFAP immunopositivity in a grey matter region of interest in the middle temporal gyrus, in 19 patients undergoing temporal lobe resection for refractory epilepsy. There were no significant correlations between any quantitative neuropathological measure and grey matter probability values in normal-appearing grey matter using either segmentation program. The lack of correlation between grey matter probability values and the cortical neuropathological measures in normal-appearing grey matter suggests that intrinsic cortical changes of the type we have measured do not influence grey matter probability maps used for VBM analyses.
机译：基于体素的形态计量学（VBM）通常用于研究患有各种疾病的患者的大脑形态学的系统差异，通常是通过与对照组进行比较。然而，经常有人提出，VBM对灰质的成分变化也很敏感。用VBM识别的灰质变化的性质仍知之甚少。当前研究的目的是确定神经元组织或神经胶质细胞的灰质组织病理学测量是否影响了用于VBM分析的灰质概率值。灰质概率值（通过SPM5和FSL-FAST获得）与神经元密度，中颞回感兴趣灰质区域中感兴趣的灰质区域的神经元密度以及NeuN和GFAP免疫阳性的视野分数相关，在19例行颞叶切除术治疗难治性患者中癫痫。使用任一分割程序，任何定量神经病理学测量值与正常出现的灰质中灰质概率值之间均无显着相关性。正常出现的灰质中灰质概率值与皮质神经病理学指标之间缺乏相关性，这表明我们所测量类型的内在皮质变化不会影响用于VBM分析的灰质概率图。

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