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首页> 外文期刊>Journal of Neuroscience Methods >Granger causality relationships between local field potentials in an animal model of temporal lobe epilepsy.
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Granger causality relationships between local field potentials in an animal model of temporal lobe epilepsy.

机译：颞叶癫痫动物模型中局部场电位之间的格兰杰因果关系。

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摘要

An understanding of the in vivo spatial emergence of abnormal brain activity during spontaneous seizure onset is critical to future early seizure detection and closed-loop seizure prevention therapies. In this study, we use Granger causality (GC) to determine the strength and direction of relationships between local field potentials (LFPs) recorded from bilateral microelectrode arrays in an intermittent spontaneous seizure model of chronic temporal lobe epilepsy before, during, and after Racine grade partial onset generalized seizures. Our results indicate distinct patterns of directional GC relationships within the hippocampus, specifically from the CA1 subfield to the dentate gyrus, prior to and during seizure onset. Our results suggest sequential and hierarchical temporal relationships between the CA1 and dentate gyrus within and across hippocampal hemispheres during seizure. Additionally, our analysis suggests a reversal in the direction of GC relationships during seizure, from an abnormal pattern to more anatomically expected pattern. This reversal correlates well with the observed behavioral transition from tonic to clonic seizure in time-locked video. These findings highlight the utility of GC to reveal dynamic directional temporal relationships between multichannel LFP recordings from multiple brain regions during unprovoked spontaneous seizures.
机译：了解自发性发作期间大脑活动异常的体内空间出现对于将来早期发作检测和闭环发作预防治疗至关重要。在这项研究中，我们使用Granger因果关系（GC）确定在Racine级之前，期间和之后的间歇性自发性癫痫发作模型中，从双边微电极阵列记录的局部场电势（LFP）之间关系的强度和方向部分发作广泛性发作。我们的结果表明，癫痫发作之前和发作期间，海马内定向GC关系的模式不同，尤其是从CA1子域到齿状回。我们的结果表明，癫痫发作期间，CA1与海马半球内和跨海马的齿状回之间存在时序和层次的时间关系。此外，我们的分析表明癫痫发作期间GC关系的方向发生了逆转，从异常模式到更符合解剖学的预期模式。这种逆转与在时间锁定视频中观察到的从强直性癫痫发作到阵挛性癫痫发作的行为转变非常相关。这些发现突出了GC的实用性，可揭示无故自发性癫痫发作期间来自多个大脑区域的多通道LFP记录之间的动态方向时间关系。

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