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首页> 外文期刊>Journal of Neuroscience Methods >Methylphenidate attenuates rats' preference for a novel spatial stimulus introduced into a familiar environment: assessment using a force-plate actometer.
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Methylphenidate attenuates rats' preference for a novel spatial stimulus introduced into a familiar environment: assessment using a force-plate actometer.

机译：哌醋甲酯减弱了大鼠对引入熟悉的环境中的新型空间刺激的偏好：使用力板式肌动计进行评估。

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摘要

Methylphenidate is a psychostimulant widely used in the treatment of attention deficit hyperactivity disorder (ADHD). Here we report a novel paradigm that affords inferences about habituation and attention to a novel stimulus in a familiar environment in a single test session without prior training of the animals. The paradigm was used to assess the effects of methylphenidate (2.5 and 5.0mg/kg, sc) in young adult, male, Long-Evans rats. Methylphenidate increased locomotor activity during the initial exposure to the test apparatus in a non-dose-related manner. However, upon introduction of a novel spatial stimulus (an alcove) in the familiar environment, methylphenidate-treatment resulted in dose-related increases in distance traveled and inhibition of long dwell times in the alcove, the latter behavior being characteristic of vehicle-treated rats' response to the alcove condition. These results demonstrate the utility of this paradigm in the elucidation of the behavioral effects of a drug commonly used in the treatment of ADHD. Findings also suggest that species-typical response preferences in rats (e.g., refuge-seeking) may emerge in experimental settings that add spatial novelty to otherwise featureless test enclosures commonly used to assess locomotor activity.
机译：哌醋甲酯是一种精神兴奋药，广泛用于治疗注意力缺陷多动障碍（ADHD）。在这里，我们报告了一种新颖的范例，该范例可以在单个测试会话中无需熟悉动物就可以在熟悉的环境中推断出习惯性和对新刺激的注意。该范例用于评估哌醋甲酯（2.5和5.0mg / kg，皮下注射）对成年雄性雄性Long-Evans大鼠的影响。哌醋甲酯在初次暴露于测试装置期间以非剂量相关的方式增加了运动活动。然而，在熟悉的环境中引入新的空间刺激（壁co）后，哌醋甲酯处理导致剂量相关的行进距离增加和壁co中长停留时间的抑制，后一种行为是经媒介物处理的大鼠的特征对凹室状况的反应。这些结果证明了该范例在阐明通常用于治疗ADHD的药物的行为效果中的效用。研究结果还表明，在实验环境中可能会出现大鼠的典型物种反应偏好（例如寻求避难所），这些实验环境为通常用于评估运动活动的无特征的试验场增加了空间新颖性。

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