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首页> 外文期刊>Journal of Neuroscience Methods >Hu, J.-Z.a , Wu, T.-D.a , Zhang, T.a , Zhao, Y.-F.b , Pang, J.b , Lu, H.-B.c Three-dimensional alteration of microvasculature in a rat model of traumatic spinal cord injury
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Hu, J.-Z.a , Wu, T.-D.a , Zhang, T.a , Zhao, Y.-F.b , Pang, J.b , Lu, H.-B.c Three-dimensional alteration of microvasculature in a rat model of traumatic spinal cord injury

机译：胡建中，吴建中，张建中，赵艳芳，庞建中，陆汉宝。大鼠脊髓损伤模型中微血管的三维变化

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摘要

Acute spinal cord injury (SCI) always leads to severe destruction of the microvascular networks. To investigate the three-dimensional (3D) alterations of microvasculature following SCI, we utilized an established rat SCI model. Based on the hypothesis that the spinal cord would undergo reorganization and postinjury modification of the vascular networks after SCI, we reconstructed the normal and injured angioarchitecture using micro-CT images of silicone rubber microsphere-perfused specimens. Several morphometric parameters were used to study the 3D vascular alterations in the SCI rat model, including the casting-based vessel volume fraction, connectivity density, separation, thickness and thickness distribution. Our results indicated that the microvascular spatial conformations were significantly different between the normal and injured spinal cord segments. The morphometric changes showed an increase of the vessel volume fraction and separation and a decrease of vessel connectivity density during the vascular healing process after SCI. Our results may contribute to elucidation of the mechanisms of compensatory vascular reconstitution in traumatized spinal cord. The method used here has the potential to improve our understanding of changes in the spatial architecture of vascular networks after SCI compared to the conventional histomorphology techniques. In summary, we developed a new methodology to analyze neurovascular pathology based on 3D vascular network patterns and features in an experimental rat SCI model. This technique could be used as a complementary tool to investigate the efficacy and side effects of therapeutic drugs or rehabilitation regimens.
机译：急性脊髓损伤（SCI）始终会导致微血管网络的严重破坏。为了研究SCI后微血管的三维（3D）改变，我们利用了已建立的大鼠SCI模型。基于SCI后脊髓将经历血管网络的重组和损伤后修饰的假说，我们使用硅橡胶微球灌注标本的微CT图像重建了正常和受伤的血管结构。几个形态学参数用于研究SCI大鼠模型中的3D血管改变，包括基于铸件的血管体积分数，连接密度，分离度，厚度和厚度分布。我们的结果表明，正常和受损脊髓节段之间的微血管空间构象均存在显着差异。形态学变化显示，在SCI后的血管愈合过程中，血管体积分数和分离度增加，血管连接密度降低。我们的结果可能有助于阐明创伤性脊髓中代偿性血管重建的机制。与传统的组织形态学技术相比，此处使用的方法具有改善我们对SCI后血管网络空间结构变化的理解的潜力。总之，我们开发了一种基于3D血管网络模式和实验大鼠SCI模型中特征的神经血管病理学分析新方法。该技术可以用作研究治疗药物或康复方案的功效和副作用的补充工具。

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