...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience Methods >A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain
【24h】

A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain

机译：一种新颖的四极微型驱动器，可同时记录灵长类动物大脑不同区域的多神经元

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A unique custom-made tetrode microdrive for recording from large numbers of neurons in several areas of primate brain is described as a means for assessing simultaneous neural activity in cortical and subcortical structures in nonhuman primates (NHPs) performing behavioral tasks. The microdrive device utilizes tetrode technology with up to six ultra-thin microprobe guide tubes (0.1. mm) that can be independently positioned, each containing reduced diameter tetrode and/or hexatrode microwires (0.02. mm) for recording and isolating single neuron activity. The microdrive device is mounted within the standard NHP cranial well and allows traversal of brain depths up to 40.0. mm. The advantages of this technology are demonstrated via simultaneously recorded large populations of neurons with tetrode type probes during task performance from a) primary motor cortex and deep brain structures (caudate-putamen and hippocampus) and b) multiple layers within the prefrontal cortex. The means to characterize interactions of well-isolated ensembles of neurons recorded simultaneously from different regions, as shown with this device, has not been previously available for application in primate brain. The device has extensive application to primate models for the detection and study of inoperative or maladaptive neural circuits related to human neurological disorders.
机译：一种独特的定制四极体微型驱动器，用于记录灵长类动物大脑多个区域的大量神经元，是一种评估执行行为任务的非人类灵长类动物（NHP）的皮层和皮层下结构同时神经活动的手段。该微驱动器装置采用四极杆技术，具有多达六个可独立放置的超薄微探针导管（0.1。mm），每根导管均包含直径减小的四极杆和/或六极微丝（0.02。mm），用于记录和隔离单个神经元活动。微型驱动器设备安装在标准NHP颅内孔中，并允许遍历高达40.0的大脑深度。毫米在任务执行期间，通过以下方式同时记录大量的具有四极型探针的神经元，证明了该技术的优势：a）原发性运动皮层和深层大脑结构（尾状-丘脑和海马），b）前额叶皮层中的多层。如用该装置所示，表征从不同区域同时记录的良好隔离的神经元相互作用的特征的方法，以前在灵长类动物脑中尚不可用。该设备已广泛应用于灵长类动物模型，以检测和研究与人类神经系统疾病有关的无效或适应不良的神经回路。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号