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首页> 外文期刊>Journal of Neuroscience Methods >Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts
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Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts

机译：具有高时空分辨率和双重光学对比的癫痫的光声和光学相干断层扫描

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摘要

Epilepsy mapping with high spatial and temporal resolution has great significance for both fundamental research on epileptic neurons and the clinical management of epilepsy. In this communication, we demonstrate for the first time in vivo epilepsy mapping with high spatial and temporal resolution and dual optical contrasts in an animal model. Through the variations of a depthresolved optical coherence tomography signal with optical scattering contrast, we observed that epileptic neuron activities modulated the optical refractive index of epileptic neurons and their surrounding tissue. Simultaneously, through neurovasculature coupling mechanisms and optical absorption contrast, we used photoacoustic signals to document the hemodynamic changes of the microvasculature surrounding the epileptic neurons. The epilepsy mapping results were confirmed by a simultaneously recorded electroencephalogram signal during epileptic seizure. Our new epilepsy mapping tool, with high temporal and spatial resolution and dual optical contrasts, may find many applications, such as drug development and epilepsy surgery.
机译：具有高时空分辨率的癫痫测绘对癫痫神经元的基础研究和癫痫的临床管理均具有重要意义。在这种交流中，我们首次展示了在动物模型中具有高时空分辨率和双重光学对比的体内癫痫标测。通过深度分辨光学相干断层扫描信号与光学散射对比度的变化，我们观察到癫痫神经元的活动调节了癫痫神经元及其周围组织的光学折射率。同时，通过神经脉管系统的耦合机制和光吸收对比，我们使用光声信号来记录癫痫神经元周围微脉管的血液动力学变化。癫痫发作期间同时记录的脑电图信号证实了癫痫的定位结果。我们具有高度时间和空间分辨率以及双重光学对比的新型癫痫标测工具可能会发现许多应用，例如药物开发和癫痫手术。

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