Deuteration can affect the conformational behaviour of amphiphilic alpha-helical structures.

Dennison SR; Hauss T; Dante S; Brandenburg K; Harris F; Phoenix DA

首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Deuteration can affect the conformational behaviour of amphiphilic alpha-helical structures.

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Deuteration can affect the conformational behaviour of amphiphilic alpha-helical structures.

机译：氘化可影响两亲性α-螺旋结构的构象行为。

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The replacement of hydrogen with deuterium is frequently used in conjunction with neutron diffraction to investigate peptide-membrane interaction. This isotopic substitution in an amino acid residue radically changes the neutron scatter pattern of the peptide, thereby allowing its localisation within the bilayer with the aid of derived Fourier maps. Nonetheless, this technique relies on the generally held assumption that normal and isotopically enriched protein species do not differ significantly in structure or biological activity. Recently, this assumption has been questioned and here, diffraction data from studies on a membrane interactive peptide clearly challenge the reliability of this assumption.

机译：用氘置换氢经常与中子衍射结合使用，以研究肽-膜相互作用。氨基酸残基中的这种同位素取代会从根本上改变肽的中子散射模式，从而借助衍生的傅立叶图谱将其定位在双层中。但是，该技术依赖于通常认为的正常和同位素富集的蛋白质种类在结构或生物学活性上没有显着差异的假设。最近，对该假设提出了质疑，在这里，来自膜相互作用肽研究的衍射数据明显挑战了该假设的可靠性。

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2006年第2期|共6页
作者
Dennison SR; Hauss T; Dante S; Brandenburg K; Harris F; Phoenix DA;
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正文语种 eng
中图分类生物化学;
关键词
Peptides; Molecular Conformation; Membranes; Affect; allowing; 肽类; 分子构象; 膜; 情感;

机译：Peptides;Molecular Conformation;Membranes;Affect;allowing;肽类;分子构象;膜;情感;

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1. Deuteration can affect the conformational behaviour of amphiphilic alpha-helical structures. [J] . Dennison SR, Hauss T, Dante S, Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2006,第2期

机译：氘化可影响两亲性α-螺旋结构的构象行为。
2. Design, synthesis, structure and properties of an alpha-helix cap template derived from N-[(2S)-2-chloropropionyl]-(2S)-Pro-(2R)-Ala-(2S,4S)-4-thioPro-OMe which initiates alpha-helical structures. [J] . Gani D., Rutherford T., Wilkie J., Tetrahedron . 1998,第52期

机译：从N-[（2S）-2-氯丙酰基]-（2S）-Pro-（2R）-Ala-（2S，4S）-4-thioPro-衍生的α-螺旋帽模板的设计，合成，结构和性质引发α-螺旋结构的OMe。
3. The sequence TGAAKAVALVL from glyceraidehyde-3-phosphate dehydrogenase displays structural ambivalence and interconverts between alpha-helical and beta-hairpin conformations mediated by collapsed conformational states [J] . Patel S, Balaji PV, Sasidhar YU Journal of peptide science: An official publication of the European Peptide Society . 2007,第5期

机译：甘油-3-磷酸脱氢酶的序列TGAAKAVALVL显示结构歧义并由折叠的构象态介导的α-螺旋构象和β-发夹构象之间的相互转化
4. COMPETITION BETWEEN ALPHA-HELICAL AND GLOBULAR CONFORMATIONS OF TRANSMEMBRANE PEPTIDE VARIANTS IN THE GAS PHASE [C] . Florian Albrieux, Hisham Ben Hamidane, Fabien Chirot, European Fourier Transform Mass Spectrometry Workshop . 2010

机译：气相中跨膜肽变体的α-螺旋和球状概性之间的竞争
5. Part I: Stucture and dynamics of beta-amyloid fibrils. Part II: Design of Taxol (Paclitaxel) analogs and predictive models; design of measles virus inhibitors; conformational analysis of alpha-helical mimics. [D] . Lakdawala, Ami Sailesh. 2004

机译：第一部分：β-淀粉样蛋白原纤维的结构和动力学。第二部分：紫杉醇（紫杉醇）类似物和预测模型的设计；麻疹病毒抑制剂的设计； α-螺旋模拟物的构象分析。
6. The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures. [O] . U Görne-Tschelnokow, A Strecker, C Kaduk, 1994

机译：烟碱乙酰胆碱受体的跨膜结构域包含α-螺旋和β结构。
7. Conformational Effect on the Bridgehead Reaction of Bicyclo3.3.1nonan-2-ones. A Facile Bridgehead Deuteration of a Bicyclo3.3.1nonan-2-one Derivative with the Cyclohexanone Ring Locked in the Boat Conformation [O] . Kiyoyuki Yamada, Shunichi Manabe, Yoshinori Kyotani, 1979

机译：诸如鲍西3.3.1诺南2-桥的桥梁反应的构象效应。双环桥梁的容易桥头氘氘珠粉丝珠诺-2-一种衍生物，其锁定在船上的环己酮环

Deuteration can affect the conformational behaviour of amphiphilic alpha-helical structures.

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