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首页> 外文期刊>Journal of Neuroscience Research >Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination.
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Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination.

机译：在脱髓鞘/髓鞘再生期间，成熟的少突胶质细胞凋亡先于IGF-1产生，少突胶质细胞祖细胞积累和分化。

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摘要

We have documented changes in the oligodendrocyte population during demyelinating insult to the adult CNS. Feeding of cuprizone to adult mice led to apoptotic death of mature oligodendrocytes followed by profound demyelination of the corpus callosum. A regenerative response was initiated even during active demyelination. Oligodendrocyte progenitors have begun to proliferate and then accumulate within the lesion. Many of these cells may have migrated from the sub-ventricular zone and fornix before their accumulation in the demyelinating corpus callosum. The accumulation of differentiating oligodendrocyte progenitors was followed closely by the reappearance of mature oligodendrocytes and remyelination. Interestingly, an increase in IGF-1 mRNA was detected at Week 3 through Week 7, suggesting potential involvement in remyelination. Other factors, however, such as PDGF, NT3, FGF, jagged, and notch remained unchanged. These results suggest that the mature oligodendroglial population depleted by apoptosis is replaced by a newly formed oligodendroglial population derived from progenitors; these accumulate and seem to differentiate during remyelination. Copyright 2000 Wiley-Liss, Inc.
机译：我们已经记录了成年中枢神经系统脱髓鞘损伤期间少突胶质细胞群的变化。给成年小鼠喂食铜酮会导致成熟的少突胶质细胞凋亡死亡，然后使call体深度脱髓鞘。即使在主动脱髓鞘过程中也开始产生再生反应。少突胶质细胞祖细胞已开始增殖，然后在病变内积聚。这些细胞中的许多可能在积聚在脱髓鞘call体中之前已从脑室下区和穹ni迁移。分化少突胶质细胞祖细胞的积累紧跟着成熟少突胶质细胞的再出现和髓鞘再生。有趣的是，在第3周到第7周检测到了IGF-1 mRNA的增加，表明可能参与了髓鞘再生。然而，其他因素，例如PDGF，NT3，FGF，锯齿状和缺口保持不变。这些结果表明，被细胞凋亡耗尽的成熟少突胶质细胞群被新形成的来源于祖细胞的少突胶质细胞群所替代。这些积累并且似乎在髓鞘再生期间分化。版权所有2000 Wiley-Liss，Inc.

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